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- W2776546700 abstract "// Lei Li 1, * , Haiming Sun 2, * , Zhijun Sun 3, * , Xin Huang 1 , Xiao Li 4 , Lihua Sun 5 , Lei Zhang 1 , Xiaodan Zhang 1 , Longwei Ye 1 , Jie Yuan 1 , Limin Mao 6 and Guolin Li 6 1 Department of Preventive Dentistry, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China 2 Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China 3 Department of Public Health, People’s Hospital of Rongcheng, Rongcheng, 264300, China 4 Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China 5 Department of Dentistry, The Electric Power Hospital of Heilongjiang Province, Harbin, 150030, China 6 Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China * These authors contributed equally to this work Correspondence to: Limin Mao, email: hao621126@126.com Guolin Li, email: liguolin@126.com Keywords: c-Met; head and neck cancer; meta-analysis; prognosis Received: August 09, 2017 Accepted: October 29, 2017 Epub: December 23, 2017 ABSTRACT The prognostic role of c-Met expression in head and neck cancer patients were controversial among different studies. Thus, we performed a meta-analysis to evaluate the relationships between c-Met expression and survival and clinical parameters of head and neck cancer patients. The databases PubMed and Embase were searched. Summary hazard ratio (HR) and 95% confidence intervals (CIs) were calculated to analyze the correlations between c-Met expression and overall survival (OS), and disease-free survival (DFS). Furthermore odds ratios (ORs) and 95% CIs were used to describe the relationships between c-Met expression and different clinicophathological parameters. A total of 2,417 patients from 19 studies were enrolled in the final analysis. The results showed that c-Met expression was significantly associated with OS (HR: 1.65; 95% CI: 1.20–2.27, P = 0.002) while not DFS (HR: 1.48, 95% CI: 0.99–2.20, P = 0.055). And c-Met expression was associated with the N stage of head and neck cancer patients (OR: 2.11; 95% CI: 1.12–3.96, P = 0.02). These results suggested that c-Met expression was a risk factor for head and neck cancer; increased c-Met expression could be a predictor of a poorer prognosis for the patients." @default.
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- W2776546700 date "2017-12-23" @default.
- W2776546700 modified "2023-09-25" @default.
- W2776546700 title "WITHDRAWN: A meta-analysis of c-Met expression in head and neck cancer" @default.
- W2776546700 doi "https://doi.org/10.18632/oncotarget.23656" @default.
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