FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2776683513> ?p ?o ?g. }

• W2776683513 abstract "ABSTRACT Background Rhabdoid tumor is a highly aggressive pediatric cancer characterized by biallelic loss and/or mutation of SMARCB1 . Outcomes remain poor, and there are no established ways to target the tumorigenic pathways driven by SMARCB1 inactivation. SMARCB1 loss leads to an increase in cyclin D transcription. Procedure We characterized the cell line WT-CLS1, which has been described previously as Wilms tumor, by whole-exome sequencing, RNA-seq, and xenograft histology. We measured the effect of microRNA overexpression on WT-CLS1, BT-12, and CHLA-06-ATRT. Results We found that WT-CLS1 demonstrates the histological, mutational, and transcriptional hallmarks of rhabdoid tumor. Because the microRNAs let-7 and miR-16 can target cyclin D genes, we next overexpressed each of these microRNAs in WT-CLS1. We found that miR-16 reduced cell accumulation. This was accompanied by a decrease in proliferation markers and an increase in apoptosis markers. These results were replicated in the BT-12 and CHLA-06-ATRT cell lines. Conclusions The loss-of-function SMARCB1 mutation found in WT-CLS1, in conjunction with immunohistochemical and gene expression analysis, warrants reclassification of this cell line as rhabdoid tumor. Proliferation of WT-CLS1 and other rhabdoid tumor cell lines is significantly abrogated by miR-16 overexpression. Further studies are necessary to gain insight into the potential for miR-16 to be used as a novel therapeutic in rhabdoid tumor. Abbreviations (ATRT) atypical teratoid/rhabdoid tumor (miRNA) microRNA (dox) doxycycline (OD595) optical density at 595 nm (CDK4) cyclin-dependent kinase 4" @default.
• W2776683513 created "2018-01-05" @default.
• W2776683513 creator A5019067908 @default.
• W2776683513 creator A5027668952 @default.
• W2776683513 creator A5032313369 @default.
• W2776683513 creator A5043357160 @default.
• W2776683513 creator A5050939925 @default.
• W2776683513 creator A5067535832 @default.
• W2776683513 creator A5086083448 @default.
• W2776683513 creator A5087551014 @default.
• W2776683513 creator A5089434512 @default.
• W2776683513 date "2017-11-22" @default.
• W2776683513 modified "2023-09-23" @default.
• W2776683513 title "miR-16 Suppresses Growth of Rhabdoid Tumor Cells" @default.
• W2776683513 cites W1592922493 @default.
• W2776683513 cites W1608177368 @default.
• W2776683513 cites W1824799279 @default.
• W2776683513 cites W1965881928 @default.
• W2776683513 cites W1974773169 @default.
• W2776683513 cites W1985563073 @default.
• W2776683513 cites W1985951426 @default.
• W2776683513 cites W2002367776 @default.
• W2776683513 cites W2006501903 @default.
• W2776683513 cites W2010078128 @default.
• W2776683513 cites W2022188846 @default.
• W2776683513 cites W2031013776 @default.
• W2776683513 cites W2031063050 @default.
• W2776683513 cites W2032541751 @default.
• W2776683513 cites W2032659166 @default.
• W2776683513 cites W2035918677 @default.
• W2776683513 cites W2037036887 @default.
• W2776683513 cites W2038067635 @default.
• W2776683513 cites W2039964553 @default.
• W2776683513 cites W2042962536 @default.
• W2776683513 cites W2046368638 @default.
• W2776683513 cites W2057924308 @default.
• W2776683513 cites W2082904471 @default.
• W2776683513 cites W2084214818 @default.
• W2776683513 cites W2085781075 @default.
• W2776683513 cites W2093248369 @default.
• W2776683513 cites W2095288716 @default.
• W2776683513 cites W2099447701 @default.
• W2776683513 cites W2109113060 @default.
• W2776683513 cites W2110905563 @default.
• W2776683513 cites W2114122319 @default.
• W2776683513 cites W2114691869 @default.
• W2776683513 cites W2117482566 @default.
• W2776683513 cites W2117835048 @default.
• W2776683513 cites W2126975878 @default.
• W2776683513 cites W2128032802 @default.
• W2776683513 cites W2132310381 @default.
• W2776683513 cites W2134629862 @default.
• W2776683513 cites W2135314242 @default.
• W2776683513 cites W2139571929 @default.
• W2776683513 cites W2144793849 @default.
• W2776683513 cites W2158988231 @default.
• W2776683513 cites W2160968516 @default.
• W2776683513 cites W2162674813 @default.
• W2776683513 cites W2166670794 @default.
• W2776683513 cites W2166767983 @default.
• W2776683513 cites W2169456326 @default.
• W2776683513 cites W2259938310 @default.
• W2776683513 cites W2286341552 @default.
• W2776683513 cites W2299654235 @default.
• W2776683513 cites W2314361118 @default.
• W2776683513 cites W2548361193 @default.
• W2776683513 cites W2563878885 @default.
• W2776683513 cites W2605858714 @default.
• W2776683513 cites W2751143162 @default.
• W2776683513 doi "https://doi.org/10.1101/219709" @default.
• W2776683513 hasPublicationYear "2017" @default.
• W2776683513 type Work @default.
• W2776683513 sameAs 2776683513 @default.
• W2776683513 citedByCount "0" @default.
• W2776683513 crossrefType "posted-content" @default.
• W2776683513 hasAuthorship W2776683513A5019067908 @default.
• W2776683513 hasAuthorship W2776683513A5027668952 @default.
• W2776683513 hasAuthorship W2776683513A5032313369 @default.
• W2776683513 hasAuthorship W2776683513A5043357160 @default.
• W2776683513 hasAuthorship W2776683513A5050939925 @default.
• W2776683513 hasAuthorship W2776683513A5067535832 @default.
• W2776683513 hasAuthorship W2776683513A5086083448 @default.
• W2776683513 hasAuthorship W2776683513A5087551014 @default.
• W2776683513 hasAuthorship W2776683513A5089434512 @default.
• W2776683513 hasBestOaLocation W27766835131 @default.
• W2776683513 hasConcept C104317684 @default.
• W2776683513 hasConcept C145059251 @default.
• W2776683513 hasConcept C150194340 @default.
• W2776683513 hasConcept C153911025 @default.
• W2776683513 hasConcept C167227067 @default.
• W2776683513 hasConcept C177450382 @default.
• W2776683513 hasConcept C190283241 @default.
• W2776683513 hasConcept C2775999222 @default.
• W2776683513 hasConcept C2778467961 @default.
• W2776683513 hasConcept C2780789225 @default.
• W2776683513 hasConcept C29537977 @default.
• W2776683513 hasConcept C502942594 @default.
• W2776683513 hasConcept C54355233 @default.
• W2776683513 hasConcept C62112901 @default.
• W2776683513 hasConcept C81885089 @default.

• next