FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2776803210> ?p ?o ?g. }

• W2776803210 abstract "When reading a report of a clinical trial, it should be possible to judge whether the results are relevant for your patients. Issues affecting the external validity or generalizability of a trial should therefore be reported. Our aim was to determine whether articles with published results from a complete cohort of drug trials conducted entirely or partly in general practice reported sufficient information about the trials to consider the external validity. A cohort of 196 drug trials in Norwegian general practice was previously identified from the Norwegian Medicines Agency archive with year of application for approval 1998–2007. After comprehensive literature searches, 134 journal articles reporting results published from 2000 to 2015 were identified. In these articles, we considered the reporting of the following issues relevant for external validity: reporting of the clinical setting; selection of patients before inclusion in a trial; reporting of patients’ co-morbidity, co-medication or ethnicity; choice of primary outcome; and reporting of adverse events. Of these 134 articles, only 30 (22%) reported the clinical setting of the trial. The number of patients screened before enrolment was reported in 61 articles (46%). The primary outcome of the trial was a surrogate outcome for 60 trials (45%), a clinical outcome for 39 (29%) and a patient-reported outcome for 25 (19%). Clinical details of adverse events were reported in 124 (93%) articles. Co-morbidity of included participants was reported in 54 trials (40%), co-medication in 27 (20%) and race/ethnicity in 78 (58%). The clinical setting of the trials, the selection of patients before enrolment, and co-morbidity or co-medication of participants was most commonly not reported, limiting the possibility to consider the generalizability of a trial. It may therefore be difficult for readers to judge whether drug trial results are applicable to clinical decision-making in general practice or when developing clinical guidelines." @default.
• W2776803210 created "2018-01-05" @default.
• W2776803210 creator A5036237851 @default.
• W2776803210 creator A5036282064 @default.
• W2776803210 creator A5056011702 @default.
• W2776803210 date "2017-12-01" @default.
• W2776803210 modified "2023-09-24" @default.
• W2776803210 title "Clinical drug trials in general practice: how well are external validity issues reported?" @default.
• W2776803210 cites W1823733931 @default.
• W2776803210 cites W1915515888 @default.
• W2776803210 cites W1931781407 @default.
• W2776803210 cites W1968046816 @default.
• W2776803210 cites W1980515016 @default.
• W2776803210 cites W1982803242 @default.
• W2776803210 cites W2012015791 @default.
• W2776803210 cites W2015712245 @default.
• W2776803210 cites W2019258544 @default.
• W2776803210 cites W2021316447 @default.
• W2776803210 cites W2022239173 @default.
• W2776803210 cites W2032541700 @default.
• W2776803210 cites W2042336351 @default.
• W2776803210 cites W2043990618 @default.
• W2776803210 cites W2046392066 @default.
• W2776803210 cites W2051393096 @default.
• W2776803210 cites W2063942209 @default.
• W2776803210 cites W2083885823 @default.
• W2776803210 cites W2090482282 @default.
• W2776803210 cites W2098923148 @default.
• W2776803210 cites W2108737279 @default.
• W2776803210 cites W2108924730 @default.
• W2776803210 cites W2120729896 @default.
• W2776803210 cites W2124136543 @default.
• W2776803210 cites W2125485554 @default.
• W2776803210 cites W2127960841 @default.
• W2776803210 cites W2130638588 @default.
• W2776803210 cites W2140922502 @default.
• W2776803210 cites W2142472527 @default.
• W2776803210 cites W2142522698 @default.
• W2776803210 cites W2145975717 @default.
• W2776803210 cites W2147581820 @default.
• W2776803210 cites W2153988016 @default.
• W2776803210 cites W2157539466 @default.
• W2776803210 cites W2167165853 @default.
• W2776803210 cites W2169090881 @default.
• W2776803210 cites W2171466942 @default.
• W2776803210 cites W2188787431 @default.
• W2776803210 cites W2338947551 @default.
• W2776803210 cites W2473310816 @default.
• W2776803210 cites W2500867715 @default.
• W2776803210 cites W2511112097 @default.
• W2776803210 cites W2525999137 @default.
• W2776803210 cites W2588681363 @default.
• W2776803210 cites W2615136004 @default.
• W2776803210 cites W4255772105 @default.
• W2776803210 cites W626841314 @default.
• W2776803210 doi "https://doi.org/10.1186/s12875-017-0680-7" @default.
• W2776803210 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5746953" @default.
• W2776803210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29284407" @default.
• W2776803210 hasPublicationYear "2017" @default.
• W2776803210 type Work @default.
• W2776803210 sameAs 2776803210 @default.
• W2776803210 citedByCount "14" @default.
• W2776803210 countsByYear W27768032102018 @default.
• W2776803210 countsByYear W27768032102019 @default.
• W2776803210 countsByYear W27768032102020 @default.
• W2776803210 countsByYear W27768032102021 @default.
• W2776803210 countsByYear W27768032102022 @default.
• W2776803210 crossrefType "journal-article" @default.
• W2776803210 hasAuthorship W2776803210A5036237851 @default.
• W2776803210 hasAuthorship W2776803210A5036282064 @default.
• W2776803210 hasAuthorship W2776803210A5056011702 @default.
• W2776803210 hasBestOaLocation W27768032101 @default.
• W2776803210 hasConcept C105795698 @default.
• W2776803210 hasConcept C126322002 @default.
• W2776803210 hasConcept C138885662 @default.
• W2776803210 hasConcept C15744967 @default.
• W2776803210 hasConcept C174106493 @default.
• W2776803210 hasConcept C17744445 @default.
• W2776803210 hasConcept C197934379 @default.
• W2776803210 hasConcept C199539241 @default.
• W2776803210 hasConcept C27158222 @default.
• W2776803210 hasConcept C2779473830 @default.
• W2776803210 hasConcept C2992672634 @default.
• W2776803210 hasConcept C33923547 @default.
• W2776803210 hasConcept C41895202 @default.
• W2776803210 hasConcept C512399662 @default.
• W2776803210 hasConcept C535046627 @default.
• W2776803210 hasConcept C63428231 @default.
• W2776803210 hasConcept C71924100 @default.
• W2776803210 hasConcept C72563966 @default.
• W2776803210 hasConcept C77805123 @default.
• W2776803210 hasConceptScore W2776803210C105795698 @default.
• W2776803210 hasConceptScore W2776803210C126322002 @default.
• W2776803210 hasConceptScore W2776803210C138885662 @default.
• W2776803210 hasConceptScore W2776803210C15744967 @default.
• W2776803210 hasConceptScore W2776803210C174106493 @default.
• W2776803210 hasConceptScore W2776803210C17744445 @default.
• W2776803210 hasConceptScore W2776803210C197934379 @default.
• W2776803210 hasConceptScore W2776803210C199539241 @default.
• W2776803210 hasConceptScore W2776803210C27158222 @default.

• next