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- W2776998098 abstract "Abstract Nature uses dynamic molecular platforms for the recruitment of weakly associating proteins into higher-order assemblies to achieve spatiotemporal control of signal transduction. Nanostructures that emulate this dynamic behavior require features such as plasticity, specificity and reversibility. Here we introduce a synthetic protein recruitment platform that combines the dynamics of supramolecular polymers with the programmability offered by DNA-mediated protein recruitment. Assembly of benzene-1,3,5-tricarboxamide (BTA) derivatives functionalized with a 10-nucleotide receptor strand into µm-long supramolecular BTA polymers is remarkably robust, even with high contents of DNA-functionalized BTA monomers and associated proteins. Specific recruitment of DNA-conjugated proteins on the supramolecular polymer results in a 1000-fold increase in protein complex formation, while at the same time enabling their rapid exchange along the BTA polymer. Our results establish supramolecular BTA polymers as a generic protein recruitment platform and demonstrate how assembly of protein complexes along the supramolecular polymer allows efficient and dynamic control of protein activity." @default.
- W2776998098 created "2018-01-05" @default.
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- W2776998098 date "2018-01-04" @default.
- W2776998098 modified "2023-10-04" @default.
- W2776998098 title "Controlling protein activity by dynamic recruitment on a supramolecular polymer platform" @default.
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- W2776998098 doi "https://doi.org/10.1038/s41467-017-02559-0" @default.
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- W2776998098 hasPublicationYear "2018" @default.
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