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- W2777014967 endingPage "782" @default.
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- W2777014967 abstract "Biomolecular homochirality refers to the assumption that amino acids in all living organisms were believed to be of the l-configuration. However, free d-amino acids are present in a wide variety of organisms and d-amino acid residues are also found in various peptides and proteins, being generated by enzymatic or non-enzymatic isomerization. In mammals, peptides and proteins containing d-amino acids have been linked to various diseases, and they act as novel disease biomarkers. Analytical methods capable of precisely detecting and quantifying d-amino acids in peptides and proteins are therefore important and useful, albeit their difficulty and complexity. Herein, we reviewed conventional analytical methods, especially 0h extrapolating method, and the problems of this method. For the solution of these problems, we furthermore described our recently developed, sensitive method, deuterium-hydrogen exchange method, to detect innate d-amino acid residues in peptides and proteins, and its applications to sample ovalbumin. This article is part of a Special Issue entitled: d-Amino acids: biology in the mirror, edited by Dr. Loredano Pollegioni, Dr. Jean-Pierre Mothet and Dr. Molla Gianluca." @default.
- W2777014967 created "2018-01-05" @default.
- W2777014967 creator A5021663084 @default.
- W2777014967 creator A5059626622 @default.
- W2777014967 date "2018-07-01" @default.
- W2777014967 modified "2023-10-16" @default.
- W2777014967 title "Detection and quantification of d -amino acid residues in peptides and proteins using acid hydrolysis" @default.
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- W2777014967 doi "https://doi.org/10.1016/j.bbapap.2017.12.010" @default.
- W2777014967 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29292238" @default.
- W2777014967 hasPublicationYear "2018" @default.