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- W2777072912 abstract "Allium hirtifolium Boiss and Astragalus hamosus L. are mentioned in Iranian traditional medicine documentation as therapy for a kind of dementia with the features and symptoms similar to those of Alzheimer’s disease (AD). In the present study, the effects of these herbs on neuro-inflammation and memory have been evaluated as new therapies in amyloid beta (Aβ)-induced memory impairment model. Separate groups of rats were fed with A. hirtifolium or A. hamosus extract (both 100 mg/(kg·day) −1 ) started 1 week before stereotaxic surgery to 24 h before behavioral testing (totally, for 16 successive days). The effects of oral administration of mentioned extracts on the memory and neuro-inflammation were assessed in the Aβ-injected rats. The results of this study showed that oral administration of both A. hirtifolium and A. hamosus improved the memory, examined by using Y-maze test and shuttle box apparatus. Also, Western blotting analysis of cyclooxygenase-2, interleukin-1β, and tumor necrosis factor-α showed that these herbs have ameliorating effects against the neuro-inflammation caused by Aβ. These findings suggest that the use of A. hirtifolium and A. hamosus as herbal therapy may be suitable for decreasing AD-related symptoms and treatment of other neurodegenerative disorders." @default.
- W2777072912 created "2018-01-05" @default.
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- W2777072912 date "2018-06-01" @default.
- W2777072912 modified "2023-09-26" @default.
- W2777072912 title "Dietary supplementation with <i>Allium hirtifolium</i> and/or <i>Astragalus hamosus</i> improved memory and reduced neuro-inflammation in the rat model of Alzheimer’s disease" @default.
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- W2777072912 doi "https://doi.org/10.1139/apnm-2017-0585" @default.
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