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- W2777113886 abstract "The role of neutrophil elastase (NE) is poorly understood in bronchiectasis because of the lack of preclinical data and so most of the assumptions made about NE inhibitor potential benefit is based on data from CF. In this context, NE seems to be a predictor of long-term clinical outcomes and a possible target of treatment. In order to better evaluate the role of NE in bronchiectasis, a systematic search of scientific evidence was performed.Two investigators independently performed the search on PubMed and included studies published up to May 15, 2017 according to predefined criteria. A final pool of 31 studies was included in the systematic review, with a total of 2679 patients. For each paper data of interest were extracted and reported in table.In this review sputum NE has proved useful as an inflammatory marker both in stable state bronchiectasis and during exacerbations and local or systemic antibiotic treatment. NE has also been associated with risk of exacerbation, time to next exacerbation and all-cause mortality. This study reviews also the role of NE as a specific target of treatment in bronchiectasis. Inhibition of NE is at a very early stage and future interventional studies should evaluate safety and efficacy for new molecules and formulations." @default.
- W2777113886 created "2018-01-05" @default.
- W2777113886 creator A5000350455 @default.
- W2777113886 creator A5003752591 @default.
- W2777113886 creator A5004487731 @default.
- W2777113886 creator A5064648234 @default.
- W2777113886 creator A5071827015 @default.
- W2777113886 creator A5074226809 @default.
- W2777113886 creator A5080110683 @default.
- W2777113886 creator A5080510203 @default.
- W2777113886 creator A5088693297 @default.
- W2777113886 date "2017-12-01" @default.
- W2777113886 modified "2023-10-03" @default.
- W2777113886 title "Neutrophil elastase in bronchiectasis" @default.
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