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- W2777200480 abstract "The formin Delphilin binds the glutamate receptor, GluRδ2, in dendritic spines of Purkinje cells. Both proteins play a role in learning. To understand how Delphilin functions in neurons, we studied the actin assembly properties of this formin. Formins have a conserved formin homology 2 domain, which nucleates and associates with the fast-growing end of actin filaments, influencing filament growth together with the formin homology 1 (FH1) domain. The strength of nucleation and elongation varies widely across formins. Additionally, most formins have conserved domains that regulate actin assembly through an intramolecular interaction. Delphilin is distinct from other formins in several ways: its expression is limited to Purkinje cells, it lacks classical autoinhibitory domains, and its FH1 domain has minimal proline-rich sequence. We found that Delphilin is an actin nucleator that does not accelerate elongation, although it binds to the barbed end of filaments. In addition, Delphilin exhibits a preference for actin isoforms, nucleating nonmuscle actin but not muscle actin, which has not been described or systematically studied in other formins. Finally, Delphilin is the first formin studied that is not regulated by intramolecular interactions. We speculate how the activity we observe is consistent with its localization in the small dendritic spines." @default.
- W2777200480 created "2018-01-05" @default.
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- W2777200480 date "2018-03-01" @default.
- W2777200480 modified "2023-09-28" @default.
- W2777200480 title "The neuron-specific formin Delphilin nucleates nonmuscle actin but does not enhance elongation" @default.
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- W2777200480 cites W1828912035 @default.
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- W2777200480 cites W1972250746 @default.
- W2777200480 cites W1980581068 @default.
- W2777200480 cites W1982014176 @default.
- W2777200480 cites W1984575308 @default.
- W2777200480 cites W1990356394 @default.
- W2777200480 cites W1995353831 @default.
- W2777200480 cites W1999707554 @default.
- W2777200480 cites W2001030339 @default.
- W2777200480 cites W2005768710 @default.
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- W2777200480 cites W2012948303 @default.
- W2777200480 cites W2015784090 @default.
- W2777200480 cites W2018212873 @default.
- W2777200480 cites W2019261850 @default.
- W2777200480 cites W2024095146 @default.
- W2777200480 cites W2025480988 @default.
- W2777200480 cites W2030222262 @default.
- W2777200480 cites W2031229874 @default.
- W2777200480 cites W2036535918 @default.
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- W2777200480 doi "https://doi.org/10.1091/mbc.e17-06-0363" @default.
- W2777200480 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6004577" @default.
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