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• W2777215257 abstract "Aim: We aimed to understand the biology of chronic lymphocytic leukemia (CLL) patients in Lebanon. Materials & methods: We applied conventional cytogenetic and FISH studies on Lebanese patients diagnosed with CLL and undergoing a watch and wait approach. Results: Our study disclosed 53.6% of patients with aberrant karyotypes among which 26.7% were complex karyotypes. Genetic aberrations included del(13q14) 46.4%, 14q32 translocation in 25%, trisomy 12 in 14.3%, del(17p13) and del(11q22) in 7.1% each. The deletion of 6q21/6q23 was not found in any of our patients. Conclusion: The higher prevalence of del(13q14) as a sole abnormality could be the primary event in inducing CLL. The del(17p13) and del(11q22) followed as potential drivers for progression in CLL patients with a watch and wait approach." @default.
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• W2777215257 date "2017-12-01" @default.
• W2777215257 modified "2023-10-13" @default.
• W2777215257 title "Untreated chronic lymphocytic leukemia in Lebanese patients: an observational study using standard karyotyping and FISH" @default.
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• W2777215257 doi "https://doi.org/10.2217/ijh-2017-0019" @default.
• W2777215257 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6172003" @default.
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