FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2777248768> ?p ?o ?g. }

• W2777248768 endingPage "236" @default.
• W2777248768 startingPage "233" @default.
• W2777248768 abstract "Malaria is a disease caused by Plasmodium parasites that affects hundreds of millions of people. Plasmodium proteases are involved in invasion, erythrocyte egress and degradation of host proteins. Falcipains are well-studied cysteine peptidases located in P. falciparum food vacuoles that participate in hemoglobin degradation. Cystatins are natural cysteine protease inhibitors that are implicated in a wide range of regulatory processes. Here, we report that a cystatin from sugarcane, CaneCPI-4, is selectively internalized into P. falciparum infected erythrocytes and is not processed by the parasite proteolytic machinery. Furthermore, we demonstrated the inhibition of P. falciparum cysteine proteases by CaneCPI-4, suggesting that it can exert inhibitory functions inside the parasites. The inhibition of the proteolytic activity of parasite cells is specific to this cystatin, as the addition of an anti-CaneCPI-4 antibody completely abolished the inhibition. We extended the studies to recombinant falcipain-2 and falcipain-3 and demonstrated that CaneCPI-4 strongly inhibits these enzymes, with IC50 values of 12 nM and 42 nM, respectively. We also demonstrated that CaneCPI-4 decreased the hemozoin formation in the parasites, affecting the parasitemia. Taken together, this study identified a natural molecule as a potential antimalarial that specifically targets falcipains and also contributes to a better understanding of macromolecule acquisition by Plasmodium falciparum infected RBCs." @default.
• W2777248768 created "2018-01-05" @default.
• W2777248768 creator A5005899813 @default.
• W2777248768 creator A5012539959 @default.
• W2777248768 creator A5036843344 @default.
• W2777248768 creator A5045606337 @default.
• W2777248768 creator A5046860030 @default.
• W2777248768 creator A5050750658 @default.
• W2777248768 creator A5060965609 @default.
• W2777248768 creator A5066839809 @default.
• W2777248768 creator A5078684766 @default.
• W2777248768 creator A5080088663 @default.
• W2777248768 date "2018-04-01" @default.
• W2777248768 modified "2023-10-14" @default.
• W2777248768 title "Inhibition of Plasmodium falciparum cysteine proteases by the sugarcane cystatin CaneCPI-4" @default.
• W2777248768 cites W176428930 @default.
• W2777248768 cites W1973810995 @default.
• W2777248768 cites W1976270212 @default.
• W2777248768 cites W1979487812 @default.
• W2777248768 cites W2012756675 @default.
• W2777248768 cites W2020315414 @default.
• W2777248768 cites W2023881017 @default.
• W2777248768 cites W2029985793 @default.
• W2777248768 cites W2053362827 @default.
• W2777248768 cites W2067904457 @default.
• W2777248768 cites W2068917459 @default.
• W2777248768 cites W2081640564 @default.
• W2777248768 cites W2133410145 @default.
• W2777248768 cites W2155091607 @default.
• W2777248768 cites W2161072396 @default.
• W2777248768 cites W2167500911 @default.
• W2777248768 cites W3148508445 @default.
• W2777248768 cites W4248713218 @default.
• W2777248768 doi "https://doi.org/10.1016/j.parint.2017.12.005" @default.
• W2777248768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29288140" @default.
• W2777248768 hasPublicationYear "2018" @default.
• W2777248768 type Work @default.
• W2777248768 sameAs 2777248768 @default.
• W2777248768 citedByCount "16" @default.
• W2777248768 countsByYear W27772487682018 @default.
• W2777248768 countsByYear W27772487682019 @default.
• W2777248768 countsByYear W27772487682020 @default.
• W2777248768 countsByYear W27772487682021 @default.
• W2777248768 countsByYear W27772487682022 @default.
• W2777248768 countsByYear W27772487682023 @default.
• W2777248768 crossrefType "journal-article" @default.
• W2777248768 hasAuthorship W2777248768A5005899813 @default.
• W2777248768 hasAuthorship W2777248768A5012539959 @default.
• W2777248768 hasAuthorship W2777248768A5036843344 @default.
• W2777248768 hasAuthorship W2777248768A5045606337 @default.
• W2777248768 hasAuthorship W2777248768A5046860030 @default.
• W2777248768 hasAuthorship W2777248768A5050750658 @default.
• W2777248768 hasAuthorship W2777248768A5060965609 @default.
• W2777248768 hasAuthorship W2777248768A5066839809 @default.
• W2777248768 hasAuthorship W2777248768A5078684766 @default.
• W2777248768 hasAuthorship W2777248768A5080088663 @default.
• W2777248768 hasConcept C102568950 @default.
• W2777248768 hasConcept C136764020 @default.
• W2777248768 hasConcept C159641895 @default.
• W2777248768 hasConcept C181199279 @default.
• W2777248768 hasConcept C182220744 @default.
• W2777248768 hasConcept C190062978 @default.
• W2777248768 hasConcept C190283241 @default.
• W2777248768 hasConcept C203014093 @default.
• W2777248768 hasConcept C2776714187 @default.
• W2777248768 hasConcept C2777283782 @default.
• W2777248768 hasConcept C2778048844 @default.
• W2777248768 hasConcept C2778371730 @default.
• W2777248768 hasConcept C2778675580 @default.
• W2777248768 hasConcept C2779201268 @default.
• W2777248768 hasConcept C2779548226 @default.
• W2777248768 hasConcept C2780412452 @default.
• W2777248768 hasConcept C2908725733 @default.
• W2777248768 hasConcept C3019223276 @default.
• W2777248768 hasConcept C31573885 @default.
• W2777248768 hasConcept C41008148 @default.
• W2777248768 hasConcept C55493867 @default.
• W2777248768 hasConcept C71928629 @default.
• W2777248768 hasConcept C86803240 @default.
• W2777248768 hasConcept C89423630 @default.
• W2777248768 hasConcept C95444343 @default.
• W2777248768 hasConcept C98424977 @default.
• W2777248768 hasConceptScore W2777248768C102568950 @default.
• W2777248768 hasConceptScore W2777248768C136764020 @default.
• W2777248768 hasConceptScore W2777248768C159641895 @default.
• W2777248768 hasConceptScore W2777248768C181199279 @default.
• W2777248768 hasConceptScore W2777248768C182220744 @default.
• W2777248768 hasConceptScore W2777248768C190062978 @default.
• W2777248768 hasConceptScore W2777248768C190283241 @default.
• W2777248768 hasConceptScore W2777248768C203014093 @default.
• W2777248768 hasConceptScore W2777248768C2776714187 @default.
• W2777248768 hasConceptScore W2777248768C2777283782 @default.
• W2777248768 hasConceptScore W2777248768C2778048844 @default.
• W2777248768 hasConceptScore W2777248768C2778371730 @default.
• W2777248768 hasConceptScore W2777248768C2778675580 @default.
• W2777248768 hasConceptScore W2777248768C2779201268 @default.
• W2777248768 hasConceptScore W2777248768C2779548226 @default.
• W2777248768 hasConceptScore W2777248768C2780412452 @default.

• next