FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2777251116> ?p ?o ?g. }

• W2777251116 endingPage "2501" @default.
• W2777251116 startingPage "2475" @default.
• W2777251116 abstract "While tamoxifen (TAM) is used for treating estrogen receptor (ER)a-positive breast cancer patients, its anti-breast cancer mechanisms are not completely elucidated. This study aimed to examine effects of 4-hydroxyltamoxifen (4-OH-TAM) on ER-positive (ER+) breast cancer MCF-7 cell growth and gene expression profiles. MCF-7 cell growth was inhibited by 4-OH-TAM dose-dependently with IC50 of 29 μM. 332 genes were up-regulated while 320 genes were down-regulated. The mRNA levels of up-regulated genes including STAT1, STAT2, EIF2AK2, TGM2, DDX58, PARP9, SASH1, RBL2 and USP18 as well as down-regulated genes including CCDN1, S100A9, S100A8, ANXA1 and PGR were confirmed by quantitative real-time PCR (qRT-PCR). In human breast tumor tissues, mRNA levels of EIF2Ak2, USP18, DDX58, RBL2, STAT2, PGR, S1000A9, and CCND1 were significantly higher in ER+- than in ER--breast cancer tissues. The mRNA levels of EIF2AK2, TGM2, USP18, DDX58, PARP9, STAT2, STAT1, PGR and CCND1 were all significantly higher in ER+-tumor tissues than in their corresponding tumor-adjacent tissues. These genes, except PGR and CCND1 which were down-regulated, were also up-regulated in ER+ MCF-7 cells by 4-OH-TAM. Total 14 genes mentioned above are involved in regulation of cell proliferation, apoptosis, cell cycles, and estrogen and interferon signal pathways. Bioinformatics analysis also revealed other novel and important regulatory factors that are associated with these genes and involved in the mentioned functional processes. This study has paved a foundation for elucidating TAM anti-breast cancer mechanisms in E2/ER-dependent and independent pathways." @default.
• W2777251116 created "2018-01-05" @default.
• W2777251116 creator A5027084758 @default.
• W2777251116 creator A5036613268 @default.
• W2777251116 creator A5039016693 @default.
• W2777251116 creator A5082213642 @default.
• W2777251116 date "2017-12-20" @default.
• W2777251116 modified "2023-10-13" @default.
• W2777251116 title "Identification of differentially expressed genes in human breast cancer cells induced by 4-hydroxyltamoxifen and elucidation of their pathophysiological relevance and mechanisms" @default.
• W2777251116 cites W1521028081 @default.
• W2777251116 cites W1548640328 @default.
• W2777251116 cites W1562190372 @default.
• W2777251116 cites W1782393501 @default.
• W2777251116 cites W1872184424 @default.
• W2777251116 cites W1912339700 @default.
• W2777251116 cites W1966204486 @default.
• W2777251116 cites W196785825 @default.
• W2777251116 cites W1968801319 @default.
• W2777251116 cites W1969461545 @default.
• W2777251116 cites W1984459365 @default.
• W2777251116 cites W1986141453 @default.
• W2777251116 cites W1989539191 @default.
• W2777251116 cites W1989643615 @default.
• W2777251116 cites W1991384441 @default.
• W2777251116 cites W1993797093 @default.
• W2777251116 cites W1995675713 @default.
• W2777251116 cites W2000493107 @default.
• W2777251116 cites W2008048656 @default.
• W2777251116 cites W2011048413 @default.
• W2777251116 cites W2026809679 @default.
• W2777251116 cites W2027684828 @default.
• W2777251116 cites W2028551949 @default.
• W2777251116 cites W2028691872 @default.
• W2777251116 cites W2033601733 @default.
• W2777251116 cites W2037322614 @default.
• W2777251116 cites W2037763398 @default.
• W2777251116 cites W2038809664 @default.
• W2777251116 cites W2052086185 @default.
• W2777251116 cites W2058006073 @default.
• W2777251116 cites W2069379552 @default.
• W2777251116 cites W2069714222 @default.
• W2777251116 cites W2070977079 @default.
• W2777251116 cites W2071910000 @default.
• W2777251116 cites W207779167 @default.
• W2777251116 cites W2081438440 @default.
• W2777251116 cites W2085237060 @default.
• W2777251116 cites W2087582518 @default.
• W2777251116 cites W2089632061 @default.
• W2777251116 cites W2090861 @default.
• W2777251116 cites W2091340779 @default.
• W2777251116 cites W2093585770 @default.
• W2777251116 cites W2097397907 @default.
• W2777251116 cites W2097839570 @default.
• W2777251116 cites W2099535971 @default.
• W2777251116 cites W2101979288 @default.
• W2777251116 cites W2102270242 @default.
• W2777251116 cites W2106787323 @default.
• W2777251116 cites W2106860625 @default.
• W2777251116 cites W2117342688 @default.
• W2777251116 cites W2118204028 @default.
• W2777251116 cites W2123087478 @default.
• W2777251116 cites W2126824378 @default.
• W2777251116 cites W2127821993 @default.
• W2777251116 cites W2128605357 @default.
• W2777251116 cites W2136690547 @default.
• W2777251116 cites W2137082708 @default.
• W2777251116 cites W2141691294 @default.
• W2777251116 cites W2145648359 @default.
• W2777251116 cites W2147255658 @default.
• W2777251116 cites W2147842136 @default.
• W2777251116 cites W2149330714 @default.
• W2777251116 cites W2149944230 @default.
• W2777251116 cites W2150205603 @default.
• W2777251116 cites W2150310725 @default.
• W2777251116 cites W2155481621 @default.
• W2777251116 cites W2161387798 @default.
• W2777251116 cites W2162638357 @default.
• W2777251116 cites W2163089079 @default.
• W2777251116 cites W2166631738 @default.
• W2777251116 cites W2170024410 @default.
• W2777251116 cites W2271190552 @default.
• W2777251116 cites W2272984102 @default.
• W2777251116 cites W2288363714 @default.
• W2777251116 cites W2290540671 @default.
• W2777251116 cites W2321112275 @default.
• W2777251116 cites W2413983988 @default.
• W2777251116 cites W2509517930 @default.
• W2777251116 cites W2525512480 @default.
• W2777251116 cites W2531506996 @default.
• W2777251116 cites W2590177834 @default.
• W2777251116 cites W2917837889 @default.
• W2777251116 cites W2921082412 @default.
• W2777251116 cites W344789099 @default.
• W2777251116 cites W4231018668 @default.
• W2777251116 cites W4234081105 @default.
• W2777251116 cites W4292308426 @default.
• W2777251116 cites W87169064 @default.
• W2777251116 doi "https://doi.org/10.18632/oncotarget.23504" @default.

• next