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• W2777252029 endingPage "113" @default.
• W2777252029 startingPage "101" @default.
• W2777252029 abstract "Candida albicans is an important source of device-associated infection because of its capacity for biofilm formation. This yeast has the ability to form biofilms which favors the persistence of the infection. Furthermore, the innate immune response has a critical role in the control of these infections and macrophages (Mø) are vital to this process. An important fungicidal mechanism employed by Mø involves the generation of toxic reactive oxygen species (ROS) and reactive nitrogen intermediates (RNI). The interaction between biofilms and these immune cells, and the contribution of oxidative and nitrosative stress, that is determinant to the course of the infection, remains elusive. The aim of this study was to investigate this interaction. To this purpose, two models of Mø-biofilms contact, early (model 1) and mature (model 2) biofilms, were used; and the production of ROS, RNI and the oxidative stress response (OSR) were evaluated. We found that the presence of Mø decreased the biofilm formation at an early stage and increased the production of ROS and RNI, with activation of ORS (enzymatic and nonenzymatic). On the other hand, the interaction between mature biofilms and Mø resulted in an increasing biofilm formation, with low levels of RNI and ROS production and decrease of OSR. Dynamic interactions between Mø and fungal biofilms were also clearly evident from images obtained by confocal scanning laser microscopy. The prooxidant-antioxidant balance was different depending of C. albicans biofilms stages and likely acts as a signal over their formation in presence of Mø. These results may contribute to a better understanding of the immune-pathogenesis of C. albicans biofilm infections." @default.
• W2777252029 created "2018-01-05" @default.
• W2777252029 creator A5029895768 @default.
• W2777252029 creator A5051463998 @default.
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• W2777252029 date "2017-12-27" @default.
• W2777252029 modified "2023-10-06" @default.
• W2777252029 title "Oxidative and nitrosative stress responses during macrophage–<i>Candida albicans</i>biofilm interaction" @default.
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• W2777252029 doi "https://doi.org/10.1093/mmy/myx143" @default.
• W2777252029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29294039" @default.
• W2777252029 hasPublicationYear "2017" @default.
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