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- W27773266 abstract "Among the enormous quantity and diversity of enzymes found in nature, researchers have confirmed the existence of only seven distinct classes of biological catalysts that are made of RNA rather than protein. As currently understood, the natural functions of these ribozymes are limited to phosphoester transfer and phosphoester hydrolysis reactions that occur with RNA or DNA substrates (Kruger et al. 1982; Guerrier-Takadaet al. 1983; Peebles et al. 1986; Paddy et al. 1986; Buzayan et al. 1986; Sharmeen et al. 1988; Saville and Collins 1990; Zimmerly et al. 1995). Although ribozymes are exceedingly rare and their biochemical functions are limited, they serve as essential components of the metabolic machinery of all living systems. It has been proposed that nucleic acids preceded proteins in the evolutionary history of biocatalysis, and that these primitive ribozymes catalyzed many of the reactions performed by modern protein enzymes (Gilbert 1986; Benner et al. 1989; Hirao and Ellington 1995). Over the course of 4 billion years of evolution, it appears that nature has determined that proteins are a superior format for constructing enzymes; however, the true capacity of nucleic acids for catalytic function remains to be fully defined." @default.
- W27773266 created "2016-06-24" @default.
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- W27773266 creator A5056049547 @default.
- W27773266 date "1999-01-01" @default.
- W27773266 modified "2023-09-24" @default.
- W27773266 title "In Vitro Selection of Nucleic Acid Enzymes" @default.
- W27773266 cites W1502906266 @default.
- W27773266 cites W1612553237 @default.
- W27773266 cites W1659671958 @default.
- W27773266 cites W1953619809 @default.
- W27773266 cites W1965464174 @default.
- W27773266 cites W1966162633 @default.
- W27773266 cites W1966909947 @default.
- W27773266 cites W1968282235 @default.
- W27773266 cites W1970032949 @default.
- W27773266 cites W1972070407 @default.
- W27773266 cites W1973352434 @default.
- W27773266 cites W1976027096 @default.
- W27773266 cites W1977233251 @default.
- W27773266 cites W1977709085 @default.
- W27773266 cites W1980230083 @default.
- W27773266 cites W1980461160 @default.
- W27773266 cites W1981087699 @default.
- W27773266 cites W1988349747 @default.
- W27773266 cites W1989794771 @default.
- W27773266 cites W1990203372 @default.
- W27773266 cites W1992821003 @default.
- W27773266 cites W1992966156 @default.
- W27773266 cites W1993835147 @default.
- W27773266 cites W1994012096 @default.
- W27773266 cites W1995675684 @default.
- W27773266 cites W1995866544 @default.
- W27773266 cites W1996715918 @default.
- W27773266 cites W1998404990 @default.
- W27773266 cites W2002854512 @default.
- W27773266 cites W2003201962 @default.
- W27773266 cites W2003711915 @default.
- W27773266 cites W2009242099 @default.
- W27773266 cites W2009396937 @default.
- W27773266 cites W2012920894 @default.
- W27773266 cites W2014601660 @default.
- W27773266 cites W2020937842 @default.
- W27773266 cites W2021333801 @default.
- W27773266 cites W2029998151 @default.
- W27773266 cites W2030304792 @default.
- W27773266 cites W2033046940 @default.
- W27773266 cites W2033231386 @default.
- W27773266 cites W2041206088 @default.
- W27773266 cites W2046880909 @default.
- W27773266 cites W2047845427 @default.
- W27773266 cites W2048602141 @default.
- W27773266 cites W2049554979 @default.
- W27773266 cites W2050956602 @default.
- W27773266 cites W2052812744 @default.
- W27773266 cites W2052832659 @default.
- W27773266 cites W2052918841 @default.
- W27773266 cites W2055467986 @default.
- W27773266 cites W2061085631 @default.
- W27773266 cites W2062756489 @default.
- W27773266 cites W2063028257 @default.
- W27773266 cites W2063219977 @default.
- W27773266 cites W2066756255 @default.
- W27773266 cites W2069020540 @default.
- W27773266 cites W2069688986 @default.
- W27773266 cites W2072879379 @default.
- W27773266 cites W2075720298 @default.
- W27773266 cites W2075903473 @default.
- W27773266 cites W2078224461 @default.
- W27773266 cites W2078427502 @default.
- W27773266 cites W2080672505 @default.
- W27773266 cites W2082844730 @default.
- W27773266 cites W2084705960 @default.
- W27773266 cites W2090909297 @default.
- W27773266 cites W2091535033 @default.
- W27773266 cites W2092205506 @default.
- W27773266 cites W2098021908 @default.
- W27773266 cites W2128606349 @default.
- W27773266 cites W2138246818 @default.
- W27773266 cites W2142408722 @default.
- W27773266 cites W226553228 @default.
- W27773266 cites W3005148357 @default.
- W27773266 cites W4236653785 @default.
- W27773266 cites W4244627260 @default.
- W27773266 doi "https://doi.org/10.1007/978-3-642-60142-2_8" @default.
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