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- W2777337959 endingPage "e0185511" @default.
- W2777337959 startingPage "e0185511" @default.
- W2777337959 abstract "Oil supplementation in dairy cattle diets is used to modulate milk fat composition, as well as the expression of mammary lipogenic genes, whose regulation remains unclear. MiRNAs are small non-coding RNA considered as crucial regulators of gene expression, offering clues to explain the mechanism underlying gene nutriregulation. The present study was designed to identify miRNAs whose expression in the cow mammary gland is modulated by sunflower oil supplementation. MiRNomes were obtained using RNAseq technology from the mammary gland of lactating cows receiving a low forage diet, supplemented or not with 4% sunflower oil. Among the 272 miRNAs characterized, eight were selected for RT-qPCR validations, showing the significant down-regulation of miR-142-5p and miR-20a-5p by sunflower supplementation. These two miRNAs are predicted to target genes whose expression was reported as differentially expressed by sunflower supplementation. Among their putative targets, ELOVL6 gene involved in lipid metabolism has been studied. However, a first analysis did not show its significant down-regulation, in response to the over-expression of miR-142-5p, of miR-20a-5p, or both, in a bovine mammary epithelial cell line. However, a clearer understanding of the miRNA expression by lipid supplementation would help to decipher the regulation of lactating cow mammary gland in response to nutrition." @default.
- W2777337959 created "2018-01-05" @default.
- W2777337959 creator A5012289862 @default.
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- W2777337959 creator A5091180171 @default.
- W2777337959 date "2017-12-27" @default.
- W2777337959 modified "2023-10-13" @default.
- W2777337959 title "Sunflower oil supplementation affects the expression of miR-20a-5p and miR-142-5p in the lactating bovine mammary gland" @default.
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- W2777337959 doi "https://doi.org/10.1371/journal.pone.0185511" @default.
- W2777337959 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5744907" @default.
- W2777337959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29281677" @default.
- W2777337959 hasPublicationYear "2017" @default.
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