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- W2777374619 abstract "Multidrug resistance (MDR) represents a major hindrance to the efficacy of cancer chemotherapeutics. While surgical resection, radiation, and chemotherapy can be used to reduce tumor size, the subsequent appearance of drug resistant cells is a frequent problem. One of the main contributors to the development of MDR is increased expression of multi-drug resistant protein 1 (MDR1), also known as P-glycoprotein (P-gp). P-gp is a membrane-associated efflux pump that can efficiently remove internalized taxane-base chemotherapeutics thus preventing drug accumulation and maintaining cellular viability. Consequently, investigation into the molecular mechanisms responsible for regulation of P-gp expression is necessary to facilitate treatment of MDR tumors. Using molecular and biochemical approaches, we identified that the micro-RNA, miRNA149, contributes to the development of MDR within malignant mesothelioma cells by regulating the expression of MDR1." @default.
- W2777374619 created "2018-01-05" @default.
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- W2777374619 date "2018-01-15" @default.
- W2777374619 modified "2023-10-11" @default.
- W2777374619 title "Micro-RNA149 confers taxane resistance to malignant mesothelioma cells via regulation of P-glycoprotein expression" @default.
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- W2777374619 doi "https://doi.org/10.1080/15384047.2017.1415677" @default.
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