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• W2777384661 abstract "Summary This retrospective study was performed to evaluate the association between the UGT 2B7 tag SNP s (rs12233719, rs4356975, rs7435335 and rs7441774) and breast cancer in Chinese females. Blood samples were collected from 672 patients with breast cancer and 670 healthy controls for DNA extraction. Matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry ( MALDI ‐ TOF MS ) was used to analyze UGT 2B7 polymorphisms. Dual‐luciferase reporter assays were further performed to investigate the regulatory function of UGT 2B7 tag SNP s. The frequency of rs7441774 G allele in the breast cancer cases was statistically significantly higher than in the controls (0.412 vs 0.358, P = .006; odds ratio [ OR ] = 1.27, 95% CI = 1.08‐1.48). After adjusting for conventional risk factors, individuals with the GG genotype had a higher breast cancer risk than those with the AA genotype (adjusted OR = 1.63, 95% CI = 1.18‐2.26; P = .008). The GCGG haplotype of UGT 2B7 was also associated with breast cancer ( OR = 1.22, 95% CI = 1.04‐1.45; P = .027). Meanwhile, the rs7441774 G allele could significantly decrease the transcriptional activity of the UGT 2B7 gene. This study indicates that UGT 2B7 polymorphisms may play a crucial role in the occurrence and development of breast cancer in the Han Chinese population." @default.
• W2777384661 created "2018-01-05" @default.
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• W2777384661 date "2018-02-07" @default.
• W2777384661 modified "2023-10-11" @default.
• W2777384661 title "Association between <scp>UDP</scp>‐glucuronosyltransferase 2B7 tag<scp>SNP</scp>s and breast cancer risk in Chinese females" @default.
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• W2777384661 doi "https://doi.org/10.1111/1440-1681.12908" @default.
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