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- W2777395816 abstract "Recruitment of human NK cells to porcine tissues has been demonstrated in pig organs perfused ex vivo with human blood in the early 1990s. Subsequently, the molecular mechanisms leading to adhesion and cytotoxicity in human NK cell-porcine endothelial cell (pEC) interactions have been elucidated in vitro to identify targets for therapeutic interventions. Specific molecular strategies to overcome human anti-pig NK cell responses include (1) blocking of the molecular events leading to recruitment (chemotaxis, adhesion, and transmigration), (2) expression of human MHC class I molecules on pECs that inhibit NK cells, and (3) elimination or blocking of pig ligands for activating human NK receptors. The potential of cell-based strategies including tolerogenic dendritic cells (DC) and regulatory T cells (Treg) and the latest progress using transgenic pigs genetically modified to reduce xenogeneic NK cell responses are discussed. Finally, we present the status of phenotypic and functional characterization of nonhuman primate (NHP) NK cells, essential for studying their role in xenograft rejection using preclinical pig-to-NHP models, and summarize key advances and important perspectives for future research." @default.
- W2777395816 created "2018-01-05" @default.
- W2777395816 creator A5002869436 @default.
- W2777395816 creator A5069445098 @default.
- W2777395816 creator A5070508417 @default.
- W2777395816 date "2017-01-01" @default.
- W2777395816 modified "2023-10-17" @default.
- W2777395816 title "The Role of NK Cells in Pig-to-Human Xenotransplantation" @default.
- W2777395816 cites W1480064251 @default.
- W2777395816 cites W1481502781 @default.
- W2777395816 cites W1487553748 @default.
- W2777395816 cites W1489465272 @default.
- W2777395816 cites W1515587936 @default.
- W2777395816 cites W1536891815 @default.
- W2777395816 cites W1543764819 @default.
- W2777395816 cites W1543829685 @default.
- W2777395816 cites W1554310999 @default.
- W2777395816 cites W1575960267 @default.
- W2777395816 cites W1579819711 @default.
- W2777395816 cites W1585212079 @default.
- W2777395816 cites W1652398319 @default.
- W2777395816 cites W1748444262 @default.
- W2777395816 cites W1803497476 @default.
- W2777395816 cites W1830533034 @default.
- W2777395816 cites W1855887796 @default.
- W2777395816 cites W1865702250 @default.
- W2777395816 cites W1876956443 @default.
- W2777395816 cites W1898125946 @default.
- W2777395816 cites W1922380586 @default.
- W2777395816 cites W1958596225 @default.
- W2777395816 cites W1965527238 @default.
- W2777395816 cites W1965982369 @default.
- W2777395816 cites W1967893841 @default.
- W2777395816 cites W1968118657 @default.
- W2777395816 cites W1968656573 @default.
- W2777395816 cites W1969123791 @default.
- W2777395816 cites W1969209789 @default.
- W2777395816 cites W1976930650 @default.
- W2777395816 cites W1978476799 @default.
- W2777395816 cites W1979914727 @default.
- W2777395816 cites W1982449815 @default.
- W2777395816 cites W1983059097 @default.
- W2777395816 cites W1984061256 @default.
- W2777395816 cites W1984450355 @default.
- W2777395816 cites W1984875217 @default.
- W2777395816 cites W1986094205 @default.
- W2777395816 cites W1987706787 @default.
- W2777395816 cites W1989064233 @default.
- W2777395816 cites W1990581185 @default.
- W2777395816 cites W1995106649 @default.
- W2777395816 cites W1996780605 @default.
- W2777395816 cites W2001148863 @default.
- W2777395816 cites W2005066013 @default.
- W2777395816 cites W2005165670 @default.
- W2777395816 cites W2005705806 @default.
- W2777395816 cites W2006621681 @default.
- W2777395816 cites W2006655585 @default.
- W2777395816 cites W2007632920 @default.
- W2777395816 cites W2007818972 @default.
- W2777395816 cites W2008246445 @default.
- W2777395816 cites W2008596422 @default.
- W2777395816 cites W2009368536 @default.
- W2777395816 cites W2012209476 @default.
- W2777395816 cites W2012715287 @default.
- W2777395816 cites W2012809827 @default.
- W2777395816 cites W2012994545 @default.
- W2777395816 cites W2013144842 @default.
- W2777395816 cites W2013571030 @default.
- W2777395816 cites W2013701194 @default.
- W2777395816 cites W2015835909 @default.
- W2777395816 cites W2016540646 @default.
- W2777395816 cites W2017176906 @default.
- W2777395816 cites W2017974529 @default.
- W2777395816 cites W2021170324 @default.
- W2777395816 cites W2023068438 @default.
- W2777395816 cites W2025551444 @default.
- W2777395816 cites W2026771564 @default.
- W2777395816 cites W2027880311 @default.
- W2777395816 cites W2028504328 @default.
- W2777395816 cites W2030126010 @default.
- W2777395816 cites W2033698213 @default.
- W2777395816 cites W2036909006 @default.
- W2777395816 cites W2039367225 @default.
- W2777395816 cites W2039566168 @default.
- W2777395816 cites W2041008939 @default.
- W2777395816 cites W2041131464 @default.
- W2777395816 cites W2041515126 @default.
- W2777395816 cites W2042175209 @default.
- W2777395816 cites W2042231738 @default.
- W2777395816 cites W2045646132 @default.
- W2777395816 cites W2049521751 @default.
- W2777395816 cites W2050527640 @default.
- W2777395816 cites W2051546362 @default.
- W2777395816 cites W2052708690 @default.
- W2777395816 cites W2052816795 @default.
- W2777395816 cites W2052938585 @default.
- W2777395816 cites W2053119527 @default.
- W2777395816 cites W2054165098 @default.