FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2777441678> ?p ?o ?g. }

• W2777441678 endingPage "L513" @default.
• W2777441678 startingPage "L505" @default.
• W2777441678 abstract "Cigarette smokers and people exposed to second-hand smoke are at an increased risk for pulmonary viral infections, and yet the mechanism responsible for this heightened susceptibility is not understood. To understand the effect of cigarette smoke on susceptibility to viral infection, we used an air-liquid interface culture system and exposed primary human small airway epithelial cells (SAEC) to whole cigarette smoke, followed by treatment with the viral mimetic polyinosinic polycytidylic acid (poly I:C) or influenza A virus (IAV). We found that prior smoke exposure strongly inhibited production of proinflammatory (interleukin-6 and interleukin-8) and antiviral [interferon-γ-induced protein 10 (IP-10) and interferons] mediators in SAECs in response to poly I:C and IAV infection. Impaired antiviral responses corresponded to increased infection with IAV. This was associated with a decrease in phosphorylation of the key antiviral transcription factor interferon response factor 3 (IRF3). Here, we found that cigarette smoke exposure inhibited activation of Toll-like receptor 3 (TLR3) by impairing TLR3 cleavage, which was required for downstream phosphorylation of IRF3 and production of IP-10. These results identify a novel mechanism by which cigarette smoke exposure impairs antiviral responses in lung epithelial cells, which may contribute to increased susceptibility to respiratory infections." @default.
• W2777441678 created "2018-01-05" @default.
• W2777441678 creator A5007144593 @default.
• W2777441678 creator A5034634267 @default.
• W2777441678 creator A5037828808 @default.
• W2777441678 creator A5061518461 @default.
• W2777441678 creator A5064982745 @default.
• W2777441678 creator A5065326739 @default.
• W2777441678 creator A5086563433 @default.
• W2777441678 date "2018-03-01" @default.
• W2777441678 modified "2023-10-18" @default.
• W2777441678 title "Cigarette smoke dampens antiviral signaling in small airway epithelial cells by disrupting TLR3 cleavage" @default.
• W2777441678 cites W1592851115 @default.
• W2777441678 cites W1623115463 @default.
• W2777441678 cites W1926689118 @default.
• W2777441678 cites W1932202918 @default.
• W2777441678 cites W1974278677 @default.
• W2777441678 cites W1974668319 @default.
• W2777441678 cites W1981221946 @default.
• W2777441678 cites W1993922305 @default.
• W2777441678 cites W2005884645 @default.
• W2777441678 cites W2010846919 @default.
• W2777441678 cites W2015415445 @default.
• W2777441678 cites W2023620934 @default.
• W2777441678 cites W2026295592 @default.
• W2777441678 cites W2033056070 @default.
• W2777441678 cites W2039569747 @default.
• W2777441678 cites W2043175663 @default.
• W2777441678 cites W2044772448 @default.
• W2777441678 cites W2046750158 @default.
• W2777441678 cites W2048351247 @default.
• W2777441678 cites W2058607861 @default.
• W2777441678 cites W2064221866 @default.
• W2777441678 cites W2070330056 @default.
• W2777441678 cites W2072916053 @default.
• W2777441678 cites W2085592918 @default.
• W2777441678 cites W2085601646 @default.
• W2777441678 cites W2086973624 @default.
• W2777441678 cites W2089140732 @default.
• W2777441678 cites W2092809827 @default.
• W2777441678 cites W2096372976 @default.
• W2777441678 cites W2107484609 @default.
• W2777441678 cites W2112162293 @default.
• W2777441678 cites W2117200779 @default.
• W2777441678 cites W2125522165 @default.
• W2777441678 cites W2141249815 @default.
• W2777441678 cites W2147030538 @default.
• W2777441678 cites W2164610956 @default.
• W2777441678 cites W2164851792 @default.
• W2777441678 cites W2166432084 @default.
• W2777441678 cites W2166657071 @default.
• W2777441678 cites W2167181621 @default.
• W2777441678 cites W2169126410 @default.
• W2777441678 cites W2169973614 @default.
• W2777441678 cites W2216873924 @default.
• W2777441678 cites W2301726303 @default.
• W2777441678 cites W2333947752 @default.
• W2777441678 cites W2406653178 @default.
• W2777441678 cites W2521041911 @default.
• W2777441678 cites W2553053875 @default.
• W2777441678 doi "https://doi.org/10.1152/ajplung.00406.2017" @default.
• W2777441678 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5900359" @default.
• W2777441678 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29351447" @default.
• W2777441678 hasPublicationYear "2018" @default.
• W2777441678 type Work @default.
• W2777441678 sameAs 2777441678 @default.
• W2777441678 citedByCount "30" @default.
• W2777441678 countsByYear W27774416782018 @default.
• W2777441678 countsByYear W27774416782019 @default.
• W2777441678 countsByYear W27774416782020 @default.
• W2777441678 countsByYear W27774416782021 @default.
• W2777441678 countsByYear W27774416782022 @default.
• W2777441678 countsByYear W27774416782023 @default.
• W2777441678 crossrefType "journal-article" @default.
• W2777441678 hasAuthorship W2777441678A5007144593 @default.
• W2777441678 hasAuthorship W2777441678A5034634267 @default.
• W2777441678 hasAuthorship W2777441678A5037828808 @default.
• W2777441678 hasAuthorship W2777441678A5061518461 @default.
• W2777441678 hasAuthorship W2777441678A5064982745 @default.
• W2777441678 hasAuthorship W2777441678A5065326739 @default.
• W2777441678 hasAuthorship W2777441678A5086563433 @default.
• W2777441678 hasBestOaLocation W27774416781 @default.
• W2777441678 hasConcept C126322002 @default.
• W2777441678 hasConcept C136449434 @default.
• W2777441678 hasConcept C164027704 @default.
• W2777441678 hasConcept C185592680 @default.
• W2777441678 hasConcept C203014093 @default.
• W2777441678 hasConcept C2522874641 @default.
• W2777441678 hasConcept C2776178377 @default.
• W2777441678 hasConcept C2776709828 @default.
• W2777441678 hasConcept C2776914184 @default.
• W2777441678 hasConcept C2777546802 @default.
• W2777441678 hasConcept C2777714996 @default.
• W2777441678 hasConcept C2778420691 @default.
• W2777441678 hasConcept C2780209191 @default.
• W2777441678 hasConcept C71924100 @default.
• W2777441678 hasConcept C86803240 @default.
• W2777441678 hasConcept C8891405 @default.

• next