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- W2777443673 abstract "Background: Lower airway infections (LAI) occur frequently in children with a tracheostostoma. Whether airway pathogens are risk factors for LAI is not sufficiently studied. Methods: We retrospectively analysed patient records of tracheostomised children and young adults, who were treated between 2004 to 2014 in the children´s hospital of the University of Muenster, Germany. The correlation between lower airway pathogens and the number of LAI per year (Y) was assessed by Spearman correlation coefficient (r). Results: 78 patients were enrolled into the study and had a tracheostoma (median of 58.5 months (interquartile range (IQR): 26; 73.5). The median age was 7.5 years (IQR: 3.75; 7.5), 43 (55%) patients were male. We cultured 329 lower airway secretions and found Staphylococcus aureus (n=135), Pseudomonas aeruginosa (n=90), Klebsiella pneumoniae (n=46), Hamophilus influenzae (n=37), Escherichia coli (n=37), Stenotrophomonas maltophilia (n=29), Acinetobacter baumannii (n=21), Moraxella catarrhalis (n=20) und Candida albicans (n=37). The presence of Acinetobacter baumanii (r= 0.355; p=0.001) and Stenotrophomonas maltophilia (r=0.274; p=0.015) was positively correlated to LAI/Y; Pseudomonas aeruginosa (r=0.109; p=0.342), Staphylococcus aureus (r=0.086; p=0.448) or Klebsiella pneumonia (r=0.050; p=0.664) was not correlated to LAI/Y. The duration of long term ventilation was negatively correlated to the number of LAI/Y (r=-0.549; p Discussion: Acinetobacter baumanii or Stenotrophomonas maltophilia in airway secretions may be risk factors and long term ventilation may be protective for LAI in children and young adults with a tracheostoma." @default.
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- W2777443673 date "2017-09-01" @default.
- W2777443673 modified "2023-09-27" @default.
- W2777443673 title "Acinetobacter baumanii and Stenotrophomonas maltophilia are associated with lower airway infections in tracheostomised children and young adults" @default.
- W2777443673 doi "https://doi.org/10.1183/1393003.congress-2017.pa4137" @default.
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