Matches in SemOpenAlex for { <https://semopenalex.org/work/W2777457987> ?p ?o ?g. }
- W2777457987 abstract "Abstract Recent studies show that berberine (BBR) is a highly promising drug candidate to treat various diseases such as diabetes, hyperlipidemia and cancer. However, the potential therapeutic application of BBR in clinic is very limited due to its undesired pharmacokinetic characteristic. In current study, BBR pellets of acceptable size and shape quality (for capsuling) are generated by extrusion-spheronisation. Compared to commercial BBR tablets, the BBR pellets show significant sustained drug release behaviour which is expected to improve the pharmacokinetic behaviour of BBR and thus enhance its oral bioavailability. Experimental results indicate that not only the pellet size but also the excipient permeability plays an important role in pellet drug release behaviour. Low field-nuclear magnetic resonance (LF-NMR) is used, for the first time, to investigate and compare water diffusion rate and water distribution in pellet-release medium systems. It is found that the water diffusion rate is dominated by pellet surface area, while the total amount of water diffusing into pellets is mainly related to excipient permeability. This study provides a guidance in optimisation of formulation and product morphology to generate BBR pellets with a desired release behaviour based on LF-NMR technique." @default.
- W2777457987 created "2018-01-05" @default.
- W2777457987 creator A5002455337 @default.
- W2777457987 creator A5038051055 @default.
- W2777457987 creator A5055984521 @default.
- W2777457987 creator A5074629039 @default.
- W2777457987 creator A5076728363 @default.
- W2777457987 date "2018-03-01" @default.
- W2777457987 modified "2023-09-24" @default.
- W2777457987 title "Production and investigation of sustained berberine pellet drug release system" @default.
- W2777457987 cites W1247925623 @default.
- W2777457987 cites W1839895561 @default.
- W2777457987 cites W1966163938 @default.
- W2777457987 cites W1972495105 @default.
- W2777457987 cites W1975638556 @default.
- W2777457987 cites W1981799583 @default.
- W2777457987 cites W1984079567 @default.
- W2777457987 cites W1985045809 @default.
- W2777457987 cites W1986061657 @default.
- W2777457987 cites W1986128862 @default.
- W2777457987 cites W1992007939 @default.
- W2777457987 cites W2005690644 @default.
- W2777457987 cites W2008043638 @default.
- W2777457987 cites W2011654869 @default.
- W2777457987 cites W2013533376 @default.
- W2777457987 cites W2016599223 @default.
- W2777457987 cites W2020042779 @default.
- W2777457987 cites W2029922860 @default.
- W2777457987 cites W2031732745 @default.
- W2777457987 cites W2049075678 @default.
- W2777457987 cites W2051716831 @default.
- W2777457987 cites W2052605604 @default.
- W2777457987 cites W2053964094 @default.
- W2777457987 cites W2061275221 @default.
- W2777457987 cites W2064172958 @default.
- W2777457987 cites W2075199222 @default.
- W2777457987 cites W2084138582 @default.
- W2777457987 cites W2102286625 @default.
- W2777457987 cites W2108738005 @default.
- W2777457987 cites W2126543479 @default.
- W2777457987 cites W2135107280 @default.
- W2777457987 cites W2150565783 @default.
- W2777457987 cites W2166982752 @default.
- W2777457987 cites W2235523981 @default.
- W2777457987 cites W2272399875 @default.
- W2777457987 cites W2603945637 @default.
- W2777457987 doi "https://doi.org/10.1016/j.apt.2017.12.011" @default.
- W2777457987 hasPublicationYear "2018" @default.
- W2777457987 type Work @default.
- W2777457987 sameAs 2777457987 @default.
- W2777457987 citedByCount "5" @default.
- W2777457987 countsByYear W27774579872019 @default.
- W2777457987 countsByYear W27774579872021 @default.
- W2777457987 countsByYear W27774579872022 @default.
- W2777457987 crossrefType "journal-article" @default.
- W2777457987 hasAuthorship W2777457987A5002455337 @default.
- W2777457987 hasAuthorship W2777457987A5038051055 @default.
- W2777457987 hasAuthorship W2777457987A5055984521 @default.
- W2777457987 hasAuthorship W2777457987A5074629039 @default.
- W2777457987 hasAuthorship W2777457987A5076728363 @default.
- W2777457987 hasConcept C127413603 @default.
- W2777457987 hasConcept C159985019 @default.
- W2777457987 hasConcept C17923525 @default.
- W2777457987 hasConcept C181389837 @default.
- W2777457987 hasConcept C185592680 @default.
- W2777457987 hasConcept C192562407 @default.
- W2777457987 hasConcept C2777239854 @default.
- W2777457987 hasConcept C2780116568 @default.
- W2777457987 hasConcept C2780584874 @default.
- W2777457987 hasConcept C42360764 @default.
- W2777457987 hasConcept C43617362 @default.
- W2777457987 hasConcept C71924100 @default.
- W2777457987 hasConcept C98274493 @default.
- W2777457987 hasConceptScore W2777457987C127413603 @default.
- W2777457987 hasConceptScore W2777457987C159985019 @default.
- W2777457987 hasConceptScore W2777457987C17923525 @default.
- W2777457987 hasConceptScore W2777457987C181389837 @default.
- W2777457987 hasConceptScore W2777457987C185592680 @default.
- W2777457987 hasConceptScore W2777457987C192562407 @default.
- W2777457987 hasConceptScore W2777457987C2777239854 @default.
- W2777457987 hasConceptScore W2777457987C2780116568 @default.
- W2777457987 hasConceptScore W2777457987C2780584874 @default.
- W2777457987 hasConceptScore W2777457987C42360764 @default.
- W2777457987 hasConceptScore W2777457987C43617362 @default.
- W2777457987 hasConceptScore W2777457987C71924100 @default.
- W2777457987 hasConceptScore W2777457987C98274493 @default.
- W2777457987 hasFunder F4320335787 @default.
- W2777457987 hasLocation W27774579871 @default.
- W2777457987 hasOpenAccess W2777457987 @default.
- W2777457987 hasPrimaryLocation W27774579871 @default.
- W2777457987 hasRelatedWork W1937310559 @default.
- W2777457987 hasRelatedWork W2010851270 @default.
- W2777457987 hasRelatedWork W2017789603 @default.
- W2777457987 hasRelatedWork W2186502611 @default.
- W2777457987 hasRelatedWork W2186940676 @default.
- W2777457987 hasRelatedWork W2187284705 @default.
- W2777457987 hasRelatedWork W2187867486 @default.
- W2777457987 hasRelatedWork W2318261010 @default.
- W2777457987 hasRelatedWork W2332866460 @default.
- W2777457987 hasRelatedWork W2442006469 @default.