FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2777472005> ?p ?o ?g. }

• W2777472005 endingPage "753" @default.
• W2777472005 startingPage "745" @default.
• W2777472005 abstract "In gastric cancer (GC), peritoneal dissemination (PD) occurs frequently and is incurable. In this study, we aimed to identify PD-associated genes in GC. We identified a PD-associated gene using three GC datasets: highly disseminated peritoneal GC cell lines, the Singapore dataset and The Cancer Genome Atlas (TCGA) dataset. We assessed the clinicopathological significance of the gene expression using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and performed immunohistochemical analysis for the gene in our patient cohort. We also performed survival analyses of the gene in our patient cohort, the Singapore dataset and the GSE62254 datasets. Moreover, gene set enrichment analysis (GSEA) was performed using the Singapore and TCGA datasets. Finally, in vitro experiments such as invasion/migration assays, immunofluorescence staining of actin filaments, epidermal growth factor (EGF) treatment analysis, and gene expression analysis were conducted using three gene-knockdown GC cell lines (AGS, 58As9, MKN45). ADP-ribosylation factor-like 4c (ARL4C) was identified as a PD-associated gene, and immunohistochemical analysis showed that ARL4C was overexpressed in GC cells. High ARL4C expression was associated with the depth of invasion (p < 0.01) and PD (p < 0.05) and was a poor prognostic factor (p < 0.05) in our patient cohort, the Singapore dataset and the GSE62254 dataset. ARL4C expression positively correlated with the epithelial–mesenchymal transition (EMT) gene set in GSEA. Moreover, ARL4C knockdown reduced invasion/migration capacity, SLUG expression, and the formation of lamellipodia or filopodia in AGS and 58As9 cells. Finally, EGF treatment increased ARL4C expression in MKN45 cells. ARL4C was associated with PD and was a poor prognostic factor in GC, possibly through promoting invasive capacity by activation of both EMT and motility." @default.
• W2777472005 created "2018-01-05" @default.
• W2777472005 creator A5004420462 @default.
• W2777472005 creator A5009239010 @default.
• W2777472005 creator A5013407257 @default.
• W2777472005 creator A5017227852 @default.
• W2777472005 creator A5017398620 @default.
• W2777472005 creator A5017606167 @default.
• W2777472005 creator A5018750173 @default.
• W2777472005 creator A5023016674 @default.
• W2777472005 creator A5040954950 @default.
• W2777472005 creator A5046758275 @default.
• W2777472005 creator A5063723368 @default.
• W2777472005 creator A5067430347 @default.
• W2777472005 creator A5073472318 @default.
• W2777472005 creator A5080405919 @default.
• W2777472005 date "2017-12-21" @default.
• W2777472005 modified "2023-10-17" @default.
• W2777472005 title "Identification of ARL4C as a Peritoneal Dissemination-Associated Gene and Its Clinical Significance in Gastric Cancer" @default.
• W2777472005 cites W1480422180 @default.
• W2777472005 cites W1520425169 @default.
• W2777472005 cites W1826266252 @default.
• W2777472005 cites W1927044883 @default.
• W2777472005 cites W1968065996 @default.
• W2777472005 cites W1974024530 @default.
• W2777472005 cites W1979988883 @default.
• W2777472005 cites W1991328721 @default.
• W2777472005 cites W2010149759 @default.
• W2777472005 cites W2017241959 @default.
• W2777472005 cites W2017818235 @default.
• W2777472005 cites W2027034550 @default.
• W2777472005 cites W2033576555 @default.
• W2777472005 cites W2037567462 @default.
• W2777472005 cites W2039442869 @default.
• W2777472005 cites W2048000549 @default.
• W2777472005 cites W2053387216 @default.
• W2777472005 cites W2070603704 @default.
• W2777472005 cites W2106787323 @default.
• W2777472005 cites W2107037361 @default.
• W2777472005 cites W2141195977 @default.
• W2777472005 cites W2155644389 @default.
• W2777472005 cites W2160473694 @default.
• W2777472005 cites W2180481128 @default.
• W2777472005 cites W2310968520 @default.
• W2777472005 cites W2464265868 @default.
• W2777472005 cites W2465049080 @default.
• W2777472005 doi "https://doi.org/10.1245/s10434-017-6292-6" @default.
• W2777472005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29270876" @default.
• W2777472005 hasPublicationYear "2017" @default.
• W2777472005 type Work @default.
• W2777472005 sameAs 2777472005 @default.
• W2777472005 citedByCount "34" @default.
• W2777472005 countsByYear W27774720052018 @default.
• W2777472005 countsByYear W27774720052019 @default.
• W2777472005 countsByYear W27774720052020 @default.
• W2777472005 countsByYear W27774720052021 @default.
• W2777472005 countsByYear W27774720052022 @default.
• W2777472005 countsByYear W27774720052023 @default.
• W2777472005 crossrefType "journal-article" @default.
• W2777472005 hasAuthorship W2777472005A5004420462 @default.
• W2777472005 hasAuthorship W2777472005A5009239010 @default.
• W2777472005 hasAuthorship W2777472005A5013407257 @default.
• W2777472005 hasAuthorship W2777472005A5017227852 @default.
• W2777472005 hasAuthorship W2777472005A5017398620 @default.
• W2777472005 hasAuthorship W2777472005A5017606167 @default.
• W2777472005 hasAuthorship W2777472005A5018750173 @default.
• W2777472005 hasAuthorship W2777472005A5023016674 @default.
• W2777472005 hasAuthorship W2777472005A5040954950 @default.
• W2777472005 hasAuthorship W2777472005A5046758275 @default.
• W2777472005 hasAuthorship W2777472005A5063723368 @default.
• W2777472005 hasAuthorship W2777472005A5067430347 @default.
• W2777472005 hasAuthorship W2777472005A5073472318 @default.
• W2777472005 hasAuthorship W2777472005A5080405919 @default.
• W2777472005 hasBestOaLocation W27774720052 @default.
• W2777472005 hasConcept C104317684 @default.
• W2777472005 hasConcept C121608353 @default.
• W2777472005 hasConcept C126322002 @default.
• W2777472005 hasConcept C142724271 @default.
• W2777472005 hasConcept C143998085 @default.
• W2777472005 hasConcept C150194340 @default.
• W2777472005 hasConcept C173396325 @default.
• W2777472005 hasConcept C204232928 @default.
• W2777472005 hasConcept C2779013556 @default.
• W2777472005 hasConcept C2780140570 @default.
• W2777472005 hasConcept C502942594 @default.
• W2777472005 hasConcept C54355233 @default.
• W2777472005 hasConcept C71924100 @default.
• W2777472005 hasConcept C76419328 @default.
• W2777472005 hasConcept C86803240 @default.
• W2777472005 hasConceptScore W2777472005C104317684 @default.
• W2777472005 hasConceptScore W2777472005C121608353 @default.
• W2777472005 hasConceptScore W2777472005C126322002 @default.
• W2777472005 hasConceptScore W2777472005C142724271 @default.
• W2777472005 hasConceptScore W2777472005C143998085 @default.
• W2777472005 hasConceptScore W2777472005C150194340 @default.
• W2777472005 hasConceptScore W2777472005C173396325 @default.
• W2777472005 hasConceptScore W2777472005C204232928 @default.
• W2777472005 hasConceptScore W2777472005C2779013556 @default.

• next