Matches in SemOpenAlex for { <https://semopenalex.org/work/W2777504080> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2777504080 abstract "Background: Although early onset asthma has been well characterised, data on adult onset asthma are scarce. Aims: To describe characteristics of adult onset asthma using data from 5 European electronic health record (EHR) databases in the study period 2008-2013. Methods: Asthma patients aged ≥18 yrs at diagnosis (COPD excluded) and with ≥1 year of follow-up were identified in EHR databases from the Netherlands (IPCI), Italy (HSD), UK (CPRD), Denmark (AUH) and Spain (SIDIAP). Patients were categorised into early adult onset asthma (>=18-39 yrs) or late onset asthma (>=40 yrs) based on the age at diagnosis. Characteristics were assessed at study start. Differences were tested with Chi-Square and Mann Whitney U test. The analysis was repeated in severe asthma only (use of high dose ICS + controller therapy for ≥120 days). Results: We included 504,745 patients (median age from 44.5-48.0 yrs) with asthma of whom 40,193 (8.0%) had severe asthma. The proportion of late onset asthma was 56.8% (range 56-60.1% across database) which increased to 70.4% (range 66.5-91.6%) in severe asthma. Compared to early adult onset asthma, patients with late onset asthma were less frequently atopic (range 9.2-28.7% across database vs. 21.5-39.5%), suffered more frequently from chronic rhinosinusitis (0.4-11.2% vs. 0.2-8.0%) and/or nasal polyposis (0.6-4.6% vs. 0.3-1.7%), GERD (2.8-14.3% vs. 0.9-7.5%) and obesity (10.5-72.2% vs. 9.3-54.7%) and had lower median IgE levels (63-91 vs. 108-226 IU/L)(all significant). Similar patterns were observed among severe asthma only. Conclusion: Differences in comorbidity in late onset vs. early adult onset asthma may be important for asthma management. GSK funded (PRJ2284)" @default.
- W2777504080 created "2018-01-05" @default.
- W2777504080 creator A5011711127 @default.
- W2777504080 creator A5014850022 @default.
- W2777504080 creator A5017900514 @default.
- W2777504080 creator A5018919281 @default.
- W2777504080 creator A5018969075 @default.
- W2777504080 creator A5031396246 @default.
- W2777504080 creator A5038076932 @default.
- W2777504080 creator A5042594419 @default.
- W2777504080 creator A5043710523 @default.
- W2777504080 creator A5044791081 @default.
- W2777504080 creator A5048300020 @default.
- W2777504080 creator A5048645102 @default.
- W2777504080 creator A5050436437 @default.
- W2777504080 creator A5058841396 @default.
- W2777504080 creator A5071672166 @default.
- W2777504080 creator A5082236476 @default.
- W2777504080 creator A5082649119 @default.
- W2777504080 creator A5083332623 @default.
- W2777504080 date "2017-09-01" @default.
- W2777504080 modified "2023-09-23" @default.
- W2777504080 title "Characteristics of adult onset vs. late onset asthma - a multinational database cohort study" @default.
- W2777504080 doi "https://doi.org/10.1183/1393003.congress-2017.oa316" @default.
- W2777504080 hasPublicationYear "2017" @default.
- W2777504080 type Work @default.
- W2777504080 sameAs 2777504080 @default.
- W2777504080 citedByCount "0" @default.
- W2777504080 crossrefType "proceedings-article" @default.
- W2777504080 hasAuthorship W2777504080A5011711127 @default.
- W2777504080 hasAuthorship W2777504080A5014850022 @default.
- W2777504080 hasAuthorship W2777504080A5017900514 @default.
- W2777504080 hasAuthorship W2777504080A5018919281 @default.
- W2777504080 hasAuthorship W2777504080A5018969075 @default.
- W2777504080 hasAuthorship W2777504080A5031396246 @default.
- W2777504080 hasAuthorship W2777504080A5038076932 @default.
- W2777504080 hasAuthorship W2777504080A5042594419 @default.
- W2777504080 hasAuthorship W2777504080A5043710523 @default.
- W2777504080 hasAuthorship W2777504080A5044791081 @default.
- W2777504080 hasAuthorship W2777504080A5048300020 @default.
- W2777504080 hasAuthorship W2777504080A5048645102 @default.
- W2777504080 hasAuthorship W2777504080A5050436437 @default.
- W2777504080 hasAuthorship W2777504080A5058841396 @default.
- W2777504080 hasAuthorship W2777504080A5071672166 @default.
- W2777504080 hasAuthorship W2777504080A5082236476 @default.
- W2777504080 hasAuthorship W2777504080A5082649119 @default.
- W2777504080 hasAuthorship W2777504080A5083332623 @default.
- W2777504080 hasConcept C126322002 @default.
- W2777504080 hasConcept C187212893 @default.
- W2777504080 hasConcept C2776042228 @default.
- W2777504080 hasConcept C2777014526 @default.
- W2777504080 hasConcept C2779134260 @default.
- W2777504080 hasConcept C41008148 @default.
- W2777504080 hasConcept C43270747 @default.
- W2777504080 hasConcept C71924100 @default.
- W2777504080 hasConcept C72563966 @default.
- W2777504080 hasConcept C77088390 @default.
- W2777504080 hasConceptScore W2777504080C126322002 @default.
- W2777504080 hasConceptScore W2777504080C187212893 @default.
- W2777504080 hasConceptScore W2777504080C2776042228 @default.
- W2777504080 hasConceptScore W2777504080C2777014526 @default.
- W2777504080 hasConceptScore W2777504080C2779134260 @default.
- W2777504080 hasConceptScore W2777504080C41008148 @default.
- W2777504080 hasConceptScore W2777504080C43270747 @default.
- W2777504080 hasConceptScore W2777504080C71924100 @default.
- W2777504080 hasConceptScore W2777504080C72563966 @default.
- W2777504080 hasConceptScore W2777504080C77088390 @default.
- W2777504080 hasLocation W27775040801 @default.
- W2777504080 hasOpenAccess W2777504080 @default.
- W2777504080 hasPrimaryLocation W27775040801 @default.
- W2777504080 hasRelatedWork W179958350 @default.
- W2777504080 hasRelatedWork W1844796707 @default.
- W2777504080 hasRelatedWork W2017962951 @default.
- W2777504080 hasRelatedWork W2022644416 @default.
- W2777504080 hasRelatedWork W2104291724 @default.
- W2777504080 hasRelatedWork W2141761887 @default.
- W2777504080 hasRelatedWork W2165728059 @default.
- W2777504080 hasRelatedWork W2342903336 @default.
- W2777504080 hasRelatedWork W2424863076 @default.
- W2777504080 hasRelatedWork W2463528997 @default.
- W2777504080 hasRelatedWork W2554944743 @default.
- W2777504080 hasRelatedWork W2779907208 @default.
- W2777504080 hasRelatedWork W2807201419 @default.
- W2777504080 hasRelatedWork W2905869054 @default.
- W2777504080 hasRelatedWork W2982796094 @default.
- W2777504080 hasRelatedWork W2990104157 @default.
- W2777504080 hasRelatedWork W3002951928 @default.
- W2777504080 hasRelatedWork W3032509239 @default.
- W2777504080 hasRelatedWork W3112139849 @default.
- W2777504080 hasRelatedWork W2586647622 @default.
- W2777504080 isParatext "false" @default.
- W2777504080 isRetracted "false" @default.
- W2777504080 magId "2777504080" @default.
- W2777504080 workType "article" @default.