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- W2777519954 abstract "ABSTRACT The question of to what extent large scale structure of interphase chromosomes contributes to chromosomal exchange aberrations is discussed for a long time but still remains unclear. We designed the polymer model of 3D organization of a mouse chromosome and simulated X-ray induced chromosomal aberrations exploring two alternative hypotheses: the probability of contacted damaged loci entailing a chromosomal rearrangement is (a) a constant value or (b) not constant, depending on the distribution of DNAsel-hypersensitivity peaks along the chromosome. The latter hypothesis proved to explain the experimental data better than the former, meaning that not only large-scale structure but also local chromatin alterations play a role." @default.
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- W2777519954 date "2017-11-22" @default.
- W2777519954 modified "2023-09-27" @default.
- W2777519954 title "Quantifying relationships between chromosome organization and chromosomal aberrations" @default.
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- W2777519954 doi "https://doi.org/10.1101/223859" @default.
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