Matches in SemOpenAlex for { <https://semopenalex.org/work/W2777527103> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2777527103 endingPage "167" @default.
- W2777527103 startingPage "157" @default.
- W2777527103 abstract "To analyze the effects of radiation on the reproductive tissue of male Wistar rats and to evaluate whether treatment with the Ang II AT1 receptor antagonists telmisartan and losartan mitigate the dysfunctions resulting from this exposure.Rats were randomly divided into groups: Control, Irradiated, Telmisartan, Losartan, Irradiated+Telmisartan, and Irradiated+Losartan. Single dose of 5Gy was administered directly into the scrotum, followed by treatment with telmisartan (12mg/kg/day) or losartan (34mg/kg/two times/day) for 60days. Testicular function parameters were evaluated from spermatozoa of the vas deferens. Testes were processed for histopathological and morphometric-stereological analysis. Proliferating cell nuclear antigen (PCNA) immunohistochemistry was evaluated.Radiation significantly reduced sperm motility, concentration, vitality, and increased the number of abnormal spermatozoa. Telmisartan and losartan did not significantly prevent these radiation-induced disorders. Seminiferous tubules were atrophied in both untreated and treated irradiated testes, and exhibited vacuoles, increased interstitial tissue and high number of blood vessels. However, several seminiferous tubules in recuperation were founded among damaged tubules in the testes of treated animals. The PCNA immunohistochemistry confirmed these outcomes. PCNA-positive cells were detected in dividing spermatogonia and spermatocytes from irradiated telmisartan and losartan treated rats whereas in the only-irradiated group, PCNA staining was observed in the nuclei of only the surviving spermatogonia.Under these experimental conditions, the testicular function parameters showed that radiation produced marked damage that was not reversed by treatments. However, gonadal restructuring and recovery of spermatogenesis in treated animals may to reflect attenuation of radiation-induced damages and potential start of recovery." @default.
- W2777527103 created "2018-01-05" @default.
- W2777527103 creator A5004078852 @default.
- W2777527103 creator A5020270872 @default.
- W2777527103 creator A5041814805 @default.
- W2777527103 creator A5048044825 @default.
- W2777527103 creator A5066873484 @default.
- W2777527103 date "2018-02-01" @default.
- W2777527103 modified "2023-10-14" @default.
- W2777527103 title "Effects of telmisartan and losartan on irradiated testes" @default.
- W2777527103 cites W1965553407 @default.
- W2777527103 cites W1972070688 @default.
- W2777527103 cites W1972370640 @default.
- W2777527103 cites W1975518883 @default.
- W2777527103 cites W1975563463 @default.
- W2777527103 cites W1980035903 @default.
- W2777527103 cites W1997213238 @default.
- W2777527103 cites W2031162220 @default.
- W2777527103 cites W2046438679 @default.
- W2777527103 cites W2057241188 @default.
- W2777527103 cites W2064951158 @default.
- W2777527103 cites W2074837982 @default.
- W2777527103 cites W2083820590 @default.
- W2777527103 cites W2090879053 @default.
- W2777527103 cites W2090986483 @default.
- W2777527103 cites W2143107602 @default.
- W2777527103 cites W2150655196 @default.
- W2777527103 cites W2154982767 @default.
- W2777527103 cites W2158404176 @default.
- W2777527103 cites W2159964722 @default.
- W2777527103 cites W2170124346 @default.
- W2777527103 cites W2292348062 @default.
- W2777527103 doi "https://doi.org/10.1016/j.lfs.2017.12.031" @default.
- W2777527103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29287783" @default.
- W2777527103 hasPublicationYear "2018" @default.
- W2777527103 type Work @default.
- W2777527103 sameAs 2777527103 @default.
- W2777527103 citedByCount "11" @default.
- W2777527103 countsByYear W27775271032019 @default.
- W2777527103 countsByYear W27775271032020 @default.
- W2777527103 countsByYear W27775271032021 @default.
- W2777527103 countsByYear W27775271032022 @default.
- W2777527103 countsByYear W27775271032023 @default.
- W2777527103 crossrefType "journal-article" @default.
- W2777527103 hasAuthorship W2777527103A5004078852 @default.
- W2777527103 hasAuthorship W2777527103A5020270872 @default.
- W2777527103 hasAuthorship W2777527103A5041814805 @default.
- W2777527103 hasAuthorship W2777527103A5048044825 @default.
- W2777527103 hasAuthorship W2777527103A5066873484 @default.
- W2777527103 hasBestOaLocation W27775271031 @default.
- W2777527103 hasConcept C123765429 @default.
- W2777527103 hasConcept C126322002 @default.
- W2777527103 hasConcept C134018914 @default.
- W2777527103 hasConcept C16685009 @default.
- W2777527103 hasConcept C170493617 @default.
- W2777527103 hasConcept C204232928 @default.
- W2777527103 hasConcept C2778210472 @default.
- W2777527103 hasConcept C2779716603 @default.
- W2777527103 hasConcept C2780288358 @default.
- W2777527103 hasConcept C2908929049 @default.
- W2777527103 hasConcept C34688535 @default.
- W2777527103 hasConcept C71924100 @default.
- W2777527103 hasConcept C84393581 @default.
- W2777527103 hasConcept C86803240 @default.
- W2777527103 hasConceptScore W2777527103C123765429 @default.
- W2777527103 hasConceptScore W2777527103C126322002 @default.
- W2777527103 hasConceptScore W2777527103C134018914 @default.
- W2777527103 hasConceptScore W2777527103C16685009 @default.
- W2777527103 hasConceptScore W2777527103C170493617 @default.
- W2777527103 hasConceptScore W2777527103C204232928 @default.
- W2777527103 hasConceptScore W2777527103C2778210472 @default.
- W2777527103 hasConceptScore W2777527103C2779716603 @default.
- W2777527103 hasConceptScore W2777527103C2780288358 @default.
- W2777527103 hasConceptScore W2777527103C2908929049 @default.
- W2777527103 hasConceptScore W2777527103C34688535 @default.
- W2777527103 hasConceptScore W2777527103C71924100 @default.
- W2777527103 hasConceptScore W2777527103C84393581 @default.
- W2777527103 hasConceptScore W2777527103C86803240 @default.
- W2777527103 hasFunder F4320320997 @default.
- W2777527103 hasLocation W27775271031 @default.
- W2777527103 hasLocation W27775271032 @default.
- W2777527103 hasOpenAccess W2777527103 @default.
- W2777527103 hasPrimaryLocation W27775271031 @default.
- W2777527103 hasRelatedWork W1513085247 @default.
- W2777527103 hasRelatedWork W1560543947 @default.
- W2777527103 hasRelatedWork W1969123217 @default.
- W2777527103 hasRelatedWork W1975035453 @default.
- W2777527103 hasRelatedWork W2038571733 @default.
- W2777527103 hasRelatedWork W2078197242 @default.
- W2777527103 hasRelatedWork W2098037832 @default.
- W2777527103 hasRelatedWork W2151218658 @default.
- W2777527103 hasRelatedWork W2160217587 @default.
- W2777527103 hasRelatedWork W2777527103 @default.
- W2777527103 hasVolume "194" @default.
- W2777527103 isParatext "false" @default.
- W2777527103 isRetracted "false" @default.
- W2777527103 magId "2777527103" @default.
- W2777527103 workType "article" @default.