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- W2777556543 abstract "Urine is a good biomarker source for proteomics studies but several factors may affect the urine proteome To evaluate the possible impact of glucocorticoids drugs on the urine proteome we investigated the effects of prednisone on urine proteome in a rat model Urine samples were collected from control and prednisone treated rats after drug administration The urinary proteome was analyzed using liquid chromatography ndash tandem mass spectrometry LC MS MS and proteins were identified using label free proteome quantification A total of urinary proteins were identified in rat urine Using label free quantification urinary proteins showed differential abundances after prednisone treatment A total of differential proteins and or their human orthologs have been previously reported as disease biomarkers Two differential proteins Haptoglobin and Neutrophil collagenase were validated via Western blot After functional analysis it was found that the pharmacological effects of prednisone were reflected in the urine Prednisone treatment influences urine proteome and some disease biomarkers and it should be taken into consideration in future disease biomarker studies" @default.
- W2777556543 created "2018-01-05" @default.
- W2777556543 creator A5073908949 @default.
- W2777556543 date "2017-10-06" @default.
- W2777556543 modified "2023-09-24" @default.
- W2777556543 title "Effects of Prednisone on Urinary Proteome and Disease Biomarkers in a Rat Model" @default.
- W2777556543 doi "https://doi.org/10.15406/mojpb.2017.06.00191" @default.
- W2777556543 hasPublicationYear "2017" @default.
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