FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2777576856> ?p ?o ?g. }

• W2777576856 endingPage "615" @default.
• W2777576856 startingPage "609" @default.
• W2777576856 abstract "A dedicated UNC45, Cro1, She4 (UCS) domain-containing protein assists in the Hsp90-mediated folding of the myosin head. Only weak sequence conservation exists between the single UCS protein of simple eukaryotes (She4 in budding yeast) and the two UCS proteins of higher organisms (the general cell and striated muscle UNC45s; UNC45-GC and UNC45-SM, respectively). In vertebrates, UNC45-GC facilitates cytoskeletal functions, whereas the 55% identical UNC45-SM assists assembly of the contractile apparatus of cardiac and skeletal muscles. A Saccharomyces cerevisiae she4Δ mutant, totally lacking any UCS protein, was engineered to express as its sole Hsp90 either the Hsp90α or the Hsp90β isoforms of human cytosolic Hsp90. A transient induction of the human UNC45-GC, but not UNC45-SM, could rescue the defective endocytosis in these she4Δ cells at 39 °C, irrespective of whether they possessed Hsp90α or Hsp90β. UNC45-GC-mediated rescue of the localisation of a Myo5-green fluorescent protein (GFP) fusion to cortical patches at 39 °C was more efficient in the yeast containing Hsp90α, though this may relate to more efficient functioning of Hsp90α as compared to Hsp90β in these strains. Furthermore, inducible expression of UNC45-GC, but not UNC45-SM, could partially rescue survival at a more extreme temperature (45 °C) that normally causes she4Δ mutant yeast cells to lyse. The results indicate that UCS protein function has been most conserved-yeast to man-in the UNC45-GC, not UNC45-SM. This may reflect UNC45-GC being the vertebrate UCS protein that assists formation of the actomyosin complexes needed for cytokinesis, cell morphological change, and organelle trafficking-events also facilitated by the myosins in yeast." @default.
• W2777576856 created "2018-01-05" @default.
• W2777576856 creator A5004829314 @default.
• W2777576856 creator A5009360938 @default.
• W2777576856 creator A5036578316 @default.
• W2777576856 creator A5055990769 @default.
• W2777576856 date "2017-12-29" @default.
• W2777576856 modified "2023-10-17" @default.
• W2777576856 title "UCS protein function is partially restored in the Saccharomyces cerevisiae she4 mutant with expression of the human UNC45-GC, but not UNC45-SM" @default.
• W2777576856 cites W136700416 @default.
• W2777576856 cites W1538013722 @default.
• W2777576856 cites W1920281557 @default.
• W2777576856 cites W1936931129 @default.
• W2777576856 cites W1976976020 @default.
• W2777576856 cites W1977548993 @default.
• W2777576856 cites W1983689793 @default.
• W2777576856 cites W1986815595 @default.
• W2777576856 cites W1997266868 @default.
• W2777576856 cites W1997859335 @default.
• W2777576856 cites W1998342895 @default.
• W2777576856 cites W1998418805 @default.
• W2777576856 cites W2004925961 @default.
• W2777576856 cites W2023253519 @default.
• W2777576856 cites W2028385416 @default.
• W2777576856 cites W2031638259 @default.
• W2777576856 cites W2046038671 @default.
• W2777576856 cites W2053998644 @default.
• W2777576856 cites W2078021348 @default.
• W2777576856 cites W2093082265 @default.
• W2777576856 cites W2099269199 @default.
• W2777576856 cites W2102078432 @default.
• W2777576856 cites W2129044698 @default.
• W2777576856 cites W2138618719 @default.
• W2777576856 cites W2138821198 @default.
• W2777576856 cites W2148153922 @default.
• W2777576856 cites W2157894871 @default.
• W2777576856 cites W2186787960 @default.
• W2777576856 cites W2553156496 @default.
• W2777576856 cites W269334237 @default.
• W2777576856 cites W4294232809 @default.
• W2777576856 doi "https://doi.org/10.1007/s12192-017-0870-1" @default.
• W2777576856 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6045556" @default.
• W2777576856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29288355" @default.
• W2777576856 hasPublicationYear "2017" @default.
• W2777576856 type Work @default.
• W2777576856 sameAs 2777576856 @default.
• W2777576856 citedByCount "3" @default.
• W2777576856 countsByYear W27775768562022 @default.
• W2777576856 countsByYear W27775768562023 @default.
• W2777576856 crossrefType "journal-article" @default.
• W2777576856 hasAuthorship W2777576856A5004829314 @default.
• W2777576856 hasAuthorship W2777576856A5009360938 @default.
• W2777576856 hasAuthorship W2777576856A5036578316 @default.
• W2777576856 hasAuthorship W2777576856A5055990769 @default.
• W2777576856 hasBestOaLocation W27775768561 @default.
• W2777576856 hasConcept C104317684 @default.
• W2777576856 hasConcept C123894998 @default.
• W2777576856 hasConcept C142613039 @default.
• W2777576856 hasConcept C143065580 @default.
• W2777576856 hasConcept C181199279 @default.
• W2777576856 hasConcept C205260736 @default.
• W2777576856 hasConcept C2775932338 @default.
• W2777576856 hasConcept C2777576037 @default.
• W2777576856 hasConcept C2779222958 @default.
• W2777576856 hasConcept C40767141 @default.
• W2777576856 hasConcept C53345823 @default.
• W2777576856 hasConcept C55493867 @default.
• W2777576856 hasConcept C6997183 @default.
• W2777576856 hasConcept C86803240 @default.
• W2777576856 hasConcept C95444343 @default.
• W2777576856 hasConcept C98539663 @default.
• W2777576856 hasConceptScore W2777576856C104317684 @default.
• W2777576856 hasConceptScore W2777576856C123894998 @default.
• W2777576856 hasConceptScore W2777576856C142613039 @default.
• W2777576856 hasConceptScore W2777576856C143065580 @default.
• W2777576856 hasConceptScore W2777576856C181199279 @default.
• W2777576856 hasConceptScore W2777576856C205260736 @default.
• W2777576856 hasConceptScore W2777576856C2775932338 @default.
• W2777576856 hasConceptScore W2777576856C2777576037 @default.
• W2777576856 hasConceptScore W2777576856C2779222958 @default.
• W2777576856 hasConceptScore W2777576856C40767141 @default.
• W2777576856 hasConceptScore W2777576856C53345823 @default.
• W2777576856 hasConceptScore W2777576856C55493867 @default.
• W2777576856 hasConceptScore W2777576856C6997183 @default.
• W2777576856 hasConceptScore W2777576856C86803240 @default.
• W2777576856 hasConceptScore W2777576856C95444343 @default.
• W2777576856 hasConceptScore W2777576856C98539663 @default.
• W2777576856 hasFunder F4320320342 @default.
• W2777576856 hasIssue "4" @default.
• W2777576856 hasLocation W27775768561 @default.
• W2777576856 hasLocation W27775768562 @default.
• W2777576856 hasLocation W27775768563 @default.
• W2777576856 hasLocation W27775768564 @default.
• W2777576856 hasLocation W27775768565 @default.
• W2777576856 hasOpenAccess W2777576856 @default.
• W2777576856 hasPrimaryLocation W27775768561 @default.
• W2777576856 hasRelatedWork W1595704637 @default.
• W2777576856 hasRelatedWork W1604657426 @default.

• next