Matches in SemOpenAlex for { <https://semopenalex.org/work/W2777668810> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2777668810 abstract "COPD is characterized by chronic inflammation, small airway remodeling and emphysema and remains a major public health problem. Despite reduced symptomatic medication a curative therapy is still missing. We performed cross-omics integrated enrichment analysis with the aim to identify novel underlying pathological mechanisms with potential future drug targets. C57BL/6 mice were exposed to cigarette smoke (CS) or filtered air (FA) for 6 months. Lung tissue was used to analyze both transcriptomics and proteomics. Lung tissue transcriptomics data from smokers and COPD patients was taken from NCBI GEO database GSE3776, proteomics data from Ohlmeier et al. 2016. 2D cross-omics integrated GO-term enrichment analysis was carried out with the help of InCroMAP. Gene expression profile of FA mice compared to chronic CS showed a clear separation. 614 genes and 520 proteins were differentially regulated (adjusted P Our results identify novel biological pathways common to both COPD patients and CS-exposed mice that can be further investigated on a CS-mouse model confirming the validity to evaluate new targets." @default.
- W2777668810 created "2018-01-05" @default.
- W2777668810 creator A5009672774 @default.
- W2777668810 creator A5023342647 @default.
- W2777668810 creator A5025814507 @default.
- W2777668810 creator A5028123294 @default.
- W2777668810 creator A5061069372 @default.
- W2777668810 creator A5081100238 @default.
- W2777668810 creator A5083128670 @default.
- W2777668810 creator A5088399987 @default.
- W2777668810 date "2017-09-01" @default.
- W2777668810 modified "2023-09-23" @default.
- W2777668810 title "2D cross-omics integrated enrichment analysis reveals insights into COPD pathogenesis" @default.
- W2777668810 doi "https://doi.org/10.1183/1393003.congress-2017.oa291" @default.
- W2777668810 hasPublicationYear "2017" @default.
- W2777668810 type Work @default.
- W2777668810 sameAs 2777668810 @default.
- W2777668810 citedByCount "0" @default.
- W2777668810 crossrefType "proceedings-article" @default.
- W2777668810 hasAuthorship W2777668810A5009672774 @default.
- W2777668810 hasAuthorship W2777668810A5023342647 @default.
- W2777668810 hasAuthorship W2777668810A5025814507 @default.
- W2777668810 hasAuthorship W2777668810A5028123294 @default.
- W2777668810 hasAuthorship W2777668810A5061069372 @default.
- W2777668810 hasAuthorship W2777668810A5081100238 @default.
- W2777668810 hasAuthorship W2777668810A5083128670 @default.
- W2777668810 hasAuthorship W2777668810A5088399987 @default.
- W2777668810 hasConcept C104317684 @default.
- W2777668810 hasConcept C126322002 @default.
- W2777668810 hasConcept C142724271 @default.
- W2777668810 hasConcept C150194340 @default.
- W2777668810 hasConcept C157585117 @default.
- W2777668810 hasConcept C162317418 @default.
- W2777668810 hasConcept C203014093 @default.
- W2777668810 hasConcept C207886595 @default.
- W2777668810 hasConcept C2776780178 @default.
- W2777668810 hasConcept C2776914184 @default.
- W2777668810 hasConcept C2777714996 @default.
- W2777668810 hasConcept C2780942790 @default.
- W2777668810 hasConcept C46111723 @default.
- W2777668810 hasConcept C54355233 @default.
- W2777668810 hasConcept C60644358 @default.
- W2777668810 hasConcept C70721500 @default.
- W2777668810 hasConcept C71924100 @default.
- W2777668810 hasConcept C86803240 @default.
- W2777668810 hasConceptScore W2777668810C104317684 @default.
- W2777668810 hasConceptScore W2777668810C126322002 @default.
- W2777668810 hasConceptScore W2777668810C142724271 @default.
- W2777668810 hasConceptScore W2777668810C150194340 @default.
- W2777668810 hasConceptScore W2777668810C157585117 @default.
- W2777668810 hasConceptScore W2777668810C162317418 @default.
- W2777668810 hasConceptScore W2777668810C203014093 @default.
- W2777668810 hasConceptScore W2777668810C207886595 @default.
- W2777668810 hasConceptScore W2777668810C2776780178 @default.
- W2777668810 hasConceptScore W2777668810C2776914184 @default.
- W2777668810 hasConceptScore W2777668810C2777714996 @default.
- W2777668810 hasConceptScore W2777668810C2780942790 @default.
- W2777668810 hasConceptScore W2777668810C46111723 @default.
- W2777668810 hasConceptScore W2777668810C54355233 @default.
- W2777668810 hasConceptScore W2777668810C60644358 @default.
- W2777668810 hasConceptScore W2777668810C70721500 @default.
- W2777668810 hasConceptScore W2777668810C71924100 @default.
- W2777668810 hasConceptScore W2777668810C86803240 @default.
- W2777668810 hasLocation W27776688101 @default.
- W2777668810 hasOpenAccess W2777668810 @default.
- W2777668810 hasPrimaryLocation W27776688101 @default.
- W2777668810 hasRelatedWork W2008067936 @default.
- W2777668810 hasRelatedWork W202411894 @default.
- W2777668810 hasRelatedWork W2079011191 @default.
- W2777668810 hasRelatedWork W2101411920 @default.
- W2777668810 hasRelatedWork W2126062691 @default.
- W2777668810 hasRelatedWork W2613324667 @default.
- W2777668810 hasRelatedWork W2775144572 @default.
- W2777668810 hasRelatedWork W2887957697 @default.
- W2777668810 hasRelatedWork W2890391464 @default.
- W2777668810 hasRelatedWork W2901402567 @default.
- W2777668810 hasRelatedWork W2905747836 @default.
- W2777668810 hasRelatedWork W2930176138 @default.
- W2777668810 hasRelatedWork W2940108326 @default.
- W2777668810 hasRelatedWork W2963618744 @default.
- W2777668810 hasRelatedWork W3001476873 @default.
- W2777668810 hasRelatedWork W3029414282 @default.
- W2777668810 hasRelatedWork W3092670839 @default.
- W2777668810 hasRelatedWork W3199142017 @default.
- W2777668810 hasRelatedWork W3210387792 @default.
- W2777668810 hasRelatedWork W1874073344 @default.
- W2777668810 isParatext "false" @default.
- W2777668810 isRetracted "false" @default.
- W2777668810 magId "2777668810" @default.
- W2777668810 workType "article" @default.