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- W2777673607 abstract "Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with poor prognosis. Assessment of lung disease and sensitive trial endpoints are challenging in clinical practice. Currently, functional vital capacity (FVC) is used as primary endpoint in IPF-trials as a surrogate marker for survival. Nitrogen multiple-breath gas washout (N2-MBW) is widely used in different adult and pediatric lung disease as an early and sensitive tool to assess small airway disease before large airway involvement can be detected using spirometry. The role in parenchymal disorders like IPF remains unknown. In a cross- sectional study we performed N2- MBW (ExhalyzerD, EcoMedics, Switzerland) and spirometry in 20 IPF patients (mean age 71 years) and 20 healthy subjects (mean age 47 years). We examined the correlation between N2-MBW indices, namely lung clearance index (LCI) for global and Sacin for acinary ventilation inhomogeneity, with FVC and a predictive marker for mortality (GAP stages). LCI was significantly elevated in IPF patients with 12.1±2.7 (mean±SD), compared to healthy subjects, with 7.9±0.9, p In summary, we show that N2-MBW indices are highly elevated in IPF patients and correlate well with GAP stages. Longitudinal follow-up and a larger cohort will show if these indices might be potential markers for disease severity or even future endpoints for clinical trials." @default.
- W2777673607 created "2018-01-05" @default.
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- W2777673607 date "2017-09-01" @default.
- W2777673607 modified "2023-09-28" @default.
- W2777673607 title "Nitrogen multiple breath washout indices as potentially prognostic markers in idiopathic pulmonary fibrosis" @default.
- W2777673607 doi "https://doi.org/10.1183/1393003.congress-2017.pa2218" @default.
- W2777673607 hasPublicationYear "2017" @default.
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