FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2777695939> ?p ?o ?g. }

• W2777695939 endingPage "e0190191" @default.
• W2777695939 startingPage "e0190191" @default.
• W2777695939 abstract "Vascular smooth muscle cell (VSMC) phenotypic modulation is characterized by the downregulation of SMC actin cytoskeleton proteins. Our published study shows that depletion of SM22α (aka SM22, Transgelin, an actin cytoskeleton binding protein) promotes inflammation in SMCs by activating NF-κB signal pathways both in cultured VSMCs and in response to vascular injury. The goal of this study is to investigate the underlying molecular mechanisms whereby SM22 suppresses NF-κB signaling pathways under inflammatory condition. NF-κB inducing kinase (Nik, aka MAP3K14, activated by the LTβR) is a key upstream regulator of NF-κB signal pathways. Here, we show that SM22 overexpression suppresses the expression of NIK and its downstream NF-κB canonical and noncanonical signal pathways in a VSMC line treated with a LTβR agonist. SM22 regulates NIK expression at both transcriptional and the proteasome-mediated post-translational levels in VSMCs depending on the culture condition. By qPCR, chromatin immunoprecipitation and luciferase assays, we found that Nik is a transcription target of serum response factor (SRF). Although SM22 is known to be expressed in the cytoplasm, we found that SM22 is also expressed in the nucleus where SM22 interacts with SRF to inhibit the transcription of Nik and prototypical SRF regulated genes including c-fos and Egr3. Moreover, carotid injury increases NIK expression in Sm22-/- mice, which is partially relieved by adenovirally transduced SM22. These findings reveal for the first time that SM22 is expressed in the nucleus in addition to the cytoplasm of VSMCs to regulate the transcription of Nik and its downstream proinflammatory NF-kB signal pathways as a modulator of SRF during vascular inflammation." @default.
• W2777695939 created "2018-01-05" @default.
• W2777695939 creator A5002541961 @default.
• W2777695939 creator A5011891226 @default.
• W2777695939 creator A5017680805 @default.
• W2777695939 creator A5025092645 @default.
• W2777695939 creator A5027475930 @default.
• W2777695939 creator A5033357424 @default.
• W2777695939 creator A5033799168 @default.
• W2777695939 creator A5037985694 @default.
• W2777695939 creator A5044469928 @default.
• W2777695939 creator A5055878867 @default.
• W2777695939 creator A5057431089 @default.
• W2777695939 creator A5060660072 @default.
• W2777695939 creator A5076271299 @default.
• W2777695939 creator A5081879708 @default.
• W2777695939 creator A5085365417 @default.
• W2777695939 creator A5091506580 @default.
• W2777695939 date "2017-12-28" @default.
• W2777695939 modified "2023-10-16" @default.
• W2777695939 title "SM22α suppresses cytokine-induced inflammation and the transcription of NF-κB inducing kinase (Nik) by modulating SRF transcriptional activity in vascular smooth muscle cells" @default.
• W2777695939 cites W1240518884 @default.
• W2777695939 cites W1539569543 @default.
• W2777695939 cites W1571557749 @default.
• W2777695939 cites W173128540 @default.
• W2777695939 cites W1967220699 @default.
• W2777695939 cites W1985317029 @default.
• W2777695939 cites W1985865240 @default.
• W2777695939 cites W1992718251 @default.
• W2777695939 cites W1993731501 @default.
• W2777695939 cites W2005152193 @default.
• W2777695939 cites W2005870664 @default.
• W2777695939 cites W2024256703 @default.
• W2777695939 cites W2024991882 @default.
• W2777695939 cites W2031084374 @default.
• W2777695939 cites W2035089560 @default.
• W2777695939 cites W2042872424 @default.
• W2777695939 cites W2046502194 @default.
• W2777695939 cites W2047647015 @default.
• W2777695939 cites W2048824272 @default.
• W2777695939 cites W2053897822 @default.
• W2777695939 cites W2055917979 @default.
• W2777695939 cites W2063987509 @default.
• W2777695939 cites W2075878571 @default.
• W2777695939 cites W2077535911 @default.
• W2777695939 cites W2082533282 @default.
• W2777695939 cites W2084634046 @default.
• W2777695939 cites W2091643606 @default.
• W2777695939 cites W2096628719 @default.
• W2777695939 cites W2103080635 @default.
• W2777695939 cites W2109910227 @default.
• W2777695939 cites W2114462069 @default.
• W2777695939 cites W2114667431 @default.
• W2777695939 cites W2114808160 @default.
• W2777695939 cites W2117822099 @default.
• W2777695939 cites W2121822802 @default.
• W2777695939 cites W2128410785 @default.
• W2777695939 cites W2131845382 @default.
• W2777695939 cites W2146939134 @default.
• W2777695939 cites W2147647689 @default.
• W2777695939 cites W2159722075 @default.
• W2777695939 cites W2161952636 @default.
• W2777695939 cites W2168192071 @default.
• W2777695939 cites W2181276474 @default.
• W2777695939 cites W290676631 @default.
• W2777695939 doi "https://doi.org/10.1371/journal.pone.0190191" @default.
• W2777695939 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5746259" @default.
• W2777695939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29284006" @default.
• W2777695939 hasPublicationYear "2017" @default.
• W2777695939 type Work @default.
• W2777695939 sameAs 2777695939 @default.
• W2777695939 citedByCount "12" @default.
• W2777695939 countsByYear W27776959392019 @default.
• W2777695939 countsByYear W27776959392020 @default.
• W2777695939 countsByYear W27776959392021 @default.
• W2777695939 countsByYear W27776959392022 @default.
• W2777695939 countsByYear W27776959392023 @default.
• W2777695939 crossrefType "journal-article" @default.
• W2777695939 hasAuthorship W2777695939A5002541961 @default.
• W2777695939 hasAuthorship W2777695939A5011891226 @default.
• W2777695939 hasAuthorship W2777695939A5017680805 @default.
• W2777695939 hasAuthorship W2777695939A5025092645 @default.
• W2777695939 hasAuthorship W2777695939A5027475930 @default.
• W2777695939 hasAuthorship W2777695939A5033357424 @default.
• W2777695939 hasAuthorship W2777695939A5033799168 @default.
• W2777695939 hasAuthorship W2777695939A5037985694 @default.
• W2777695939 hasAuthorship W2777695939A5044469928 @default.
• W2777695939 hasAuthorship W2777695939A5055878867 @default.
• W2777695939 hasAuthorship W2777695939A5057431089 @default.
• W2777695939 hasAuthorship W2777695939A5060660072 @default.
• W2777695939 hasAuthorship W2777695939A5076271299 @default.
• W2777695939 hasAuthorship W2777695939A5081879708 @default.
• W2777695939 hasAuthorship W2777695939A5085365417 @default.
• W2777695939 hasAuthorship W2777695939A5091506580 @default.
• W2777695939 hasBestOaLocation W27776959391 @default.
• W2777695939 hasConcept C101762097 @default.
• W2777695939 hasConcept C104317684 @default.
• W2777695939 hasConcept C125705527 @default.

• next