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- W27777584 abstract "Astroglial excitability is based on highly spatio-temporally coordinated fluctuations of intracellular ion concentrations, among which changes in Ca2+ and Na+ take the leading role. Intracellular signals mediated by Ca2+ and Na+ target numerous molecular cascades that control gene expression, energy production and numerous homeostatic functions of astrocytes. Initiation of Ca2+ and Na+ signals relies upon plasmalemmal and intracellular channels that allow fluxes of respective ions down their concentration gradients. Astrocytes express several types of TRP channels of which TRPA1 channels are linked to regulation of functional expression of GABA transporters, whereas TRPV4 channels are activated following osmotic challenges and are up-regulated in ischaemic conditions. Astrocytes also ubiquitously express several isoforms of TRPC channels of which heteromers assembled from TRPC1, 4 and/or 5 subunits that likely act as stretch-activated channels and are linked to store-operated Ca2+ entry. The TRPC channels mediate large Na+ fluxes that are associated with the endoplasmic reticulum Ca2+ signalling machinery and hence coordinate Na+ and Ca2+ signalling in astroglia." @default.
- W27777584 created "2016-06-24" @default.
- W27777584 creator A5016152202 @default.
- W27777584 creator A5018157242 @default.
- W27777584 creator A5083227570 @default.
- W27777584 date "2013-01-01" @default.
- W27777584 modified "2023-10-17" @default.
- W27777584 title "TRP Channels Coordinate Ion Signalling in Astroglia" @default.
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