Matches in SemOpenAlex for { <https://semopenalex.org/work/W2777763359> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2777763359 abstract "ImmunologyPathogenic infection has been implicated in the chronic inflammation seen in inflammatory bowel diseases (IBDs) such as ulcerative colitis and Crohn's disease. Yang et al. show that recurrent, low-level, and fully resolving Salmonella enterica Typhimurium (ST) infections can precipitate severe colonic inflammation in mice. ST-induced TLR4 activation resulted in increased neuraminidase 3 (Neu3) production and activity in the duodenum. This led to intestinal alkaline phosphatase (IAP) desialylation and degradation. IAP deficiency caused a marked increase in commensal bacteria-generated lipopolysaccharide-phosphate in the colon, provoking inflammation. Treatment with calf IAP or the antiviral drug zanamivir (which inhibits Neu3 activity) prevented this inflammatory cascade. This pathway may serve as an effective target for future human IBD therapies.Science , this issue p. [eaao5610][1] [1]: /lookup/doi/10.1126/science.aao5610" @default.
- W2777763359 created "2018-01-05" @default.
- W2777763359 creator A5010366586 @default.
- W2777763359 date "2017-12-21" @default.
- W2777763359 modified "2023-09-24" @default.
- W2777763359 title "Minor infections cause big problems" @default.
- W2777763359 doi "https://doi.org/10.1126/science.358.6370.1551-k" @default.
- W2777763359 hasPublicationYear "2017" @default.
- W2777763359 type Work @default.
- W2777763359 sameAs 2777763359 @default.
- W2777763359 citedByCount "0" @default.
- W2777763359 crossrefType "journal-article" @default.
- W2777763359 hasAuthorship W2777763359A5010366586 @default.
- W2777763359 hasConcept C126322002 @default.
- W2777763359 hasConcept C143121216 @default.
- W2777763359 hasConcept C203014093 @default.
- W2777763359 hasConcept C2775862500 @default.
- W2777763359 hasConcept C2776914184 @default.
- W2777763359 hasConcept C2778260677 @default.
- W2777763359 hasConcept C2778754761 @default.
- W2777763359 hasConcept C2779134260 @default.
- W2777763359 hasConcept C2779280984 @default.
- W2777763359 hasConcept C2780479503 @default.
- W2777763359 hasConcept C60644358 @default.
- W2777763359 hasConcept C71924100 @default.
- W2777763359 hasConcept C86803240 @default.
- W2777763359 hasConcept C89423630 @default.
- W2777763359 hasConceptScore W2777763359C126322002 @default.
- W2777763359 hasConceptScore W2777763359C143121216 @default.
- W2777763359 hasConceptScore W2777763359C203014093 @default.
- W2777763359 hasConceptScore W2777763359C2775862500 @default.
- W2777763359 hasConceptScore W2777763359C2776914184 @default.
- W2777763359 hasConceptScore W2777763359C2778260677 @default.
- W2777763359 hasConceptScore W2777763359C2778754761 @default.
- W2777763359 hasConceptScore W2777763359C2779134260 @default.
- W2777763359 hasConceptScore W2777763359C2779280984 @default.
- W2777763359 hasConceptScore W2777763359C2780479503 @default.
- W2777763359 hasConceptScore W2777763359C60644358 @default.
- W2777763359 hasConceptScore W2777763359C71924100 @default.
- W2777763359 hasConceptScore W2777763359C86803240 @default.
- W2777763359 hasConceptScore W2777763359C89423630 @default.
- W2777763359 hasLocation W27777633591 @default.
- W2777763359 hasOpenAccess W2777763359 @default.
- W2777763359 hasPrimaryLocation W27777633591 @default.
- W2777763359 hasRelatedWork W1487070367 @default.
- W2777763359 hasRelatedWork W2054870176 @default.
- W2777763359 hasRelatedWork W2058402219 @default.
- W2777763359 hasRelatedWork W2094767103 @default.
- W2777763359 hasRelatedWork W2102435892 @default.
- W2777763359 hasRelatedWork W2107302468 @default.
- W2777763359 hasRelatedWork W2376407495 @default.
- W2777763359 hasRelatedWork W2399260057 @default.
- W2777763359 hasRelatedWork W2498679748 @default.
- W2777763359 hasRelatedWork W2757294097 @default.
- W2777763359 hasRelatedWork W2777913435 @default.
- W2777763359 hasRelatedWork W2791062016 @default.
- W2777763359 hasRelatedWork W2904351369 @default.
- W2777763359 hasRelatedWork W3013529101 @default.
- W2777763359 hasRelatedWork W3135490339 @default.
- W2777763359 hasRelatedWork W3162909416 @default.
- W2777763359 hasRelatedWork W3182543611 @default.
- W2777763359 hasRelatedWork W3212238000 @default.
- W2777763359 hasRelatedWork W59836752 @default.
- W2777763359 hasRelatedWork W863521366 @default.
- W2777763359 isParatext "false" @default.
- W2777763359 isRetracted "false" @default.
- W2777763359 magId "2777763359" @default.
- W2777763359 workType "article" @default.