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- W2777773487 endingPage "520" @default.
- W2777773487 startingPage "507" @default.
- W2777773487 abstract "Purpose The purpose of this study is to develop double diffusion encoding (DDE) MRI methods for clinical use. Microscopic diffusion anisotropy measurements from DDE promise greater specificity to changes in tissue microstructure compared with conventional diffusion tensor imaging, but implementation of DDE sequences on whole‐body MRI scanners is challenging because of the limited gradient strengths and lengthy acquisition times. Methods A custom single‐refocused DDE sequence was implemented on a 3T whole‐body scanner. The DDE gradient orientation scheme and sequence parameters were optimized based on a Gaussian diffusion assumption. Using an optimized 5‐min DDE acquisition, microscopic fractional anisotropy (μFA) maps were acquired for the first time in multiple sclerosis patients. Results Based on simulations and in vivo human measurements, six parallel and six orthogonal diffusion gradient pairs were found to be the minimum number of diffusion gradient pairs necessary to produce a rotationally invariant measurement of μFA. Simulations showed that optimal precision and accuracy of μFA measurements were obtained using b‐values between 1500 and 3000 s/mm 2 . The μFA maps showed improved delineation of multiple sclerosis lesions compared with conventional fractional anisotropy and distinct contrast from T 2 ‐weighted fluid attenuated inversion recovery and T 1 ‐weighted imaging. Conclusion The μFA maps can be measured using DDE in a clinical setting and may provide new opportunities for characterizing multiple sclerosis lesions and other types of tissue degeneration. Magn Reson Med 80:507–520, 2018. © 2017 International Society for Magnetic Resonance in Medicine." @default.
- W2777773487 created "2018-01-05" @default.
- W2777773487 creator A5037873718 @default.
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- W2777773487 creator A5066843175 @default.
- W2777773487 creator A5068194964 @default.
- W2777773487 date "2017-12-19" @default.
- W2777773487 modified "2023-10-17" @default.
- W2777773487 title "Double diffusion encoding MRI for the clinic" @default.
- W2777773487 cites W1024451551 @default.
- W2777773487 cites W1498957064 @default.
- W2777773487 cites W1520858596 @default.
- W2777773487 cites W1546994556 @default.
- W2777773487 cites W1561966395 @default.
- W2777773487 cites W1821725364 @default.
- W2777773487 cites W1825115127 @default.
- W2777773487 cites W1896318329 @default.
- W2777773487 cites W1926586119 @default.
- W2777773487 cites W1953823942 @default.
- W2777773487 cites W1970791686 @default.
- W2777773487 cites W1970936375 @default.
- W2777773487 cites W1974850321 @default.
- W2777773487 cites W1978867566 @default.
- W2777773487 cites W1984016709 @default.
- W2777773487 cites W1987263024 @default.
- W2777773487 cites W1990778123 @default.
- W2777773487 cites W1992488030 @default.
- W2777773487 cites W1992502191 @default.
- W2777773487 cites W1993053013 @default.
- W2777773487 cites W1996596481 @default.
- W2777773487 cites W1999210265 @default.
- W2777773487 cites W2003536401 @default.
- W2777773487 cites W2006096283 @default.
- W2777773487 cites W2012966059 @default.
- W2777773487 cites W2013091225 @default.
- W2777773487 cites W2022468143 @default.
- W2777773487 cites W2023723060 @default.
- W2777773487 cites W2024729467 @default.
- W2777773487 cites W2032133853 @default.
- W2777773487 cites W2032254014 @default.
- W2777773487 cites W2044363734 @default.
- W2777773487 cites W2044677981 @default.
- W2777773487 cites W2046529900 @default.
- W2777773487 cites W2047248671 @default.
- W2777773487 cites W2047592445 @default.
- W2777773487 cites W2052644075 @default.
- W2777773487 cites W2053838094 @default.
- W2777773487 cites W2056199981 @default.
- W2777773487 cites W2056232814 @default.
- W2777773487 cites W2062289627 @default.
- W2777773487 cites W2063631125 @default.
- W2777773487 cites W2064080652 @default.
- W2777773487 cites W2065539222 @default.
- W2777773487 cites W2067214598 @default.
- W2777773487 cites W2068860991 @default.
- W2777773487 cites W2069127196 @default.
- W2777773487 cites W2073311133 @default.
- W2777773487 cites W2073729522 @default.
- W2777773487 cites W2082506742 @default.
- W2777773487 cites W2084761689 @default.
- W2777773487 cites W2085361905 @default.
- W2777773487 cites W2097423145 @default.
- W2777773487 cites W2101135654 @default.
- W2777773487 cites W2107956652 @default.
- W2777773487 cites W2109757784 @default.
- W2777773487 cites W2113147609 @default.
- W2777773487 cites W2116940908 @default.
- W2777773487 cites W2117987496 @default.
- W2777773487 cites W2118748898 @default.
- W2777773487 cites W2122662954 @default.
- W2777773487 cites W2127309075 @default.
- W2777773487 cites W2136133131 @default.
- W2777773487 cites W2147133578 @default.
- W2777773487 cites W2148248578 @default.
- W2777773487 cites W2150092576 @default.
- W2777773487 cites W2152046999 @default.
- W2777773487 cites W2156536300 @default.
- W2777773487 cites W2157035009 @default.
- W2777773487 cites W2161794997 @default.
- W2777773487 cites W2207563923 @default.
- W2777773487 cites W2236225132 @default.
- W2777773487 cites W2275837766 @default.
- W2777773487 cites W2301333274 @default.
- W2777773487 cites W2305147940 @default.
- W2777773487 cites W2306358050 @default.
- W2777773487 cites W2486427691 @default.
- W2777773487 cites W2492502187 @default.
- W2777773487 cites W2566713214 @default.
- W2777773487 cites W2580516708 @default.
- W2777773487 cites W2728424745 @default.
- W2777773487 cites W286895437 @default.
- W2777773487 cites W4235770099 @default.
- W2777773487 cites W4254033716 @default.
- W2777773487 cites W838115849 @default.
- W2777773487 doi "https://doi.org/10.1002/mrm.27043" @default.
- W2777773487 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5910247" @default.
- W2777773487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29266375" @default.