Matches in SemOpenAlex for { <https://semopenalex.org/work/W2777857518> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W2777857518 endingPage "55" @default.
- W2777857518 startingPage "51" @default.
- W2777857518 abstract "Introduction: Ischemia in rat brain causes severe neuronal damage and causes anxiety disorders. Ferulago angulata extracts contain phenolic compounds with powerful antioxidant activity. Therefore, the aim of this study was to evaluate the protective effect of F. angulata (Chevilan) extract on locomotor activity and anxiety in ischemia model in rats.Methods: In this experimental study, 50 male Wistar rats weighing 200 to 250 g were randomly divided into 5 groups including intact (control), ischemic hypoperfusion without extract and three groups of ischemic hypo-perfusion, for 14 days, received 100, 200 and 400 mg/kg Chevilan extracts by gavage method daily. For ischemia common bilateral carotid arteries were isolated, blocked in two parts and cut from the middle section. Locomotor activity and anxiety were evaluated during an open field testing.Results: The ischemic group showed a significant increase in anxiety and decrease in motor activity in the open field test. Administration of 100, 200 or 400 mg/kg doses of the extract significantly reduced the number of raising hands, especially at the dose of 200 (P < 0.05), and all three doses reduced the number of defecations (P < 0.001). Consumption of 400 mg/kg dose of the F. angulata extracts showed a significant increase in the number of movements in the central house in the open field and between houses margins (P < 0.05).Conclusion: Ferulago angulata extract reduces anxiety in animal models of ischemia, which is probably due to some phenolic compounds and its antioxidant activity." @default.
- W2777857518 created "2018-01-05" @default.
- W2777857518 creator A5041071136 @default.
- W2777857518 creator A5083799481 @default.
- W2777857518 date "2017-12-29" @default.
- W2777857518 modified "2023-10-04" @default.
- W2777857518 title "The effect of hydro-alcoholic Ferulago angulata extract on locomotor activity and anxiety caused by hypoperfusion ischemia in adult male rats" @default.
- W2777857518 doi "https://doi.org/10.15171/jhp.2018.09" @default.
- W2777857518 hasPublicationYear "2017" @default.
- W2777857518 type Work @default.
- W2777857518 sameAs 2777857518 @default.
- W2777857518 citedByCount "4" @default.
- W2777857518 countsByYear W27778575182019 @default.
- W2777857518 countsByYear W27778575182020 @default.
- W2777857518 countsByYear W27778575182021 @default.
- W2777857518 crossrefType "journal-article" @default.
- W2777857518 hasAuthorship W2777857518A5041071136 @default.
- W2777857518 hasAuthorship W2777857518A5083799481 @default.
- W2777857518 hasBestOaLocation W27778575181 @default.
- W2777857518 hasConcept C118552586 @default.
- W2777857518 hasConcept C126322002 @default.
- W2777857518 hasConcept C146957229 @default.
- W2777857518 hasConcept C2778004101 @default.
- W2777857518 hasConcept C2779085643 @default.
- W2777857518 hasConcept C42219234 @default.
- W2777857518 hasConcept C541997718 @default.
- W2777857518 hasConcept C55493867 @default.
- W2777857518 hasConcept C558461103 @default.
- W2777857518 hasConcept C71924100 @default.
- W2777857518 hasConcept C86803240 @default.
- W2777857518 hasConcept C98274493 @default.
- W2777857518 hasConceptScore W2777857518C118552586 @default.
- W2777857518 hasConceptScore W2777857518C126322002 @default.
- W2777857518 hasConceptScore W2777857518C146957229 @default.
- W2777857518 hasConceptScore W2777857518C2778004101 @default.
- W2777857518 hasConceptScore W2777857518C2779085643 @default.
- W2777857518 hasConceptScore W2777857518C42219234 @default.
- W2777857518 hasConceptScore W2777857518C541997718 @default.
- W2777857518 hasConceptScore W2777857518C55493867 @default.
- W2777857518 hasConceptScore W2777857518C558461103 @default.
- W2777857518 hasConceptScore W2777857518C71924100 @default.
- W2777857518 hasConceptScore W2777857518C86803240 @default.
- W2777857518 hasConceptScore W2777857518C98274493 @default.
- W2777857518 hasIssue "1" @default.
- W2777857518 hasLocation W27778575181 @default.
- W2777857518 hasOpenAccess W2777857518 @default.
- W2777857518 hasPrimaryLocation W27778575181 @default.
- W2777857518 hasRelatedWork W1984380630 @default.
- W2777857518 hasRelatedWork W2016591423 @default.
- W2777857518 hasRelatedWork W2071493161 @default.
- W2777857518 hasRelatedWork W2072813728 @default.
- W2777857518 hasRelatedWork W2134205100 @default.
- W2777857518 hasRelatedWork W2352641992 @default.
- W2777857518 hasRelatedWork W2373402090 @default.
- W2777857518 hasRelatedWork W2394372752 @default.
- W2777857518 hasRelatedWork W2549135832 @default.
- W2777857518 hasRelatedWork W2800976672 @default.
- W2777857518 hasVolume "7" @default.
- W2777857518 isParatext "false" @default.
- W2777857518 isRetracted "false" @default.
- W2777857518 magId "2777857518" @default.
- W2777857518 workType "article" @default.