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- W2777892103 abstract "The aging process is driven by interrelated mechanisms that lead to the emergence of characteristic phenotypes that include changes in body composition, energy production and utilization imbalance, homeostatic dysregulation, and neurodegeneration and loss of neuroplasticity. Mainstream theories of aging all recognize that the aging phenotypes result from an imbalance between stressors and stress buffering mechanisms and a resultant loss of compensatory reserve leading to accumulation of unrepaired damage. This in turn results in increased disease susceptibility, reduced functional reserve, reduced healing capacity and stress resistance, unstable health and finally failure to thrive. The resultant physical and cognitive decline that culminates with the frailty syndrome is a tipping point of healthspan and implies a high risk of system decompensation and death. Preserving physical and cognitive function is the main focus of geriatric and gerontological research, but it is important to recognize that accomplishing this goal requires a profound understanding of the molecular, cellular and physiological mechanisms that ultimately determine functional changes. In this context, the proinflammatory state of aging plays a major role. Longitudinal studies have shown that with aging most individuals tend to develop a chronic low-grade proinflammatory state, and that such a state is a strong risk factor for multimorbidity, physical and cognitive disability, frailty and death. A number of environmental factors may play an important role in modifying the proinflammatory state. We explore processes and mechanisms of aging that affect human biology and the possible links of inflammation and the environment to aging, especially those related to metabolism. We point out that longitudinal studies with a life course approach are needed to gain further mechanistic insight on the processes that lead to functional decline with aging, and the role played in this process by inflammation and environmental challenges." @default.
- W2777892103 created "2018-01-05" @default.
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- W2777892103 creator A5048196698 @default.
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- W2777892103 creator A5084378822 @default.
- W2777892103 date "2018-05-01" @default.
- W2777892103 modified "2023-10-16" @default.
- W2777892103 title "Aging, inflammation and the environment" @default.
- W2777892103 cites W158003248 @default.
- W2777892103 cites W1581404153 @default.
- W2777892103 cites W1594796751 @default.
- W2777892103 cites W1622777525 @default.
- W2777892103 cites W1694109520 @default.
- W2777892103 cites W170549786 @default.
- W2777892103 cites W1800944583 @default.
- W2777892103 cites W185214937 @default.
- W2777892103 cites W1878284175 @default.
- W2777892103 cites W1884934928 @default.
- W2777892103 cites W1924955228 @default.
- W2777892103 cites W1966706887 @default.
- W2777892103 cites W1976855961 @default.
- W2777892103 cites W1977724378 @default.
- W2777892103 cites W1982602899 @default.
- W2777892103 cites W1985258975 @default.
- W2777892103 cites W1987699071 @default.
- W2777892103 cites W1994540097 @default.
- W2777892103 cites W1994816987 @default.
- W2777892103 cites W1995481571 @default.
- W2777892103 cites W1995706959 @default.
- W2777892103 cites W2001953395 @default.
- W2777892103 cites W2012028008 @default.
- W2777892103 cites W2014150292 @default.
- W2777892103 cites W2024782183 @default.
- W2777892103 cites W2027042725 @default.
- W2777892103 cites W2036898624 @default.
- W2777892103 cites W2037113045 @default.
- W2777892103 cites W2040598427 @default.
- W2777892103 cites W2042084120 @default.
- W2777892103 cites W2042716686 @default.
- W2777892103 cites W2042927333 @default.
- W2777892103 cites W2044897807 @default.
- W2777892103 cites W2050552746 @default.
- W2777892103 cites W2051505451 @default.
- W2777892103 cites W2054942199 @default.
- W2777892103 cites W2056673369 @default.
- W2777892103 cites W2058881502 @default.
- W2777892103 cites W2064128267 @default.
- W2777892103 cites W2064310756 @default.
- W2777892103 cites W2067224531 @default.
- W2777892103 cites W2071170964 @default.
- W2777892103 cites W2081789109 @default.
- W2777892103 cites W2092538255 @default.
- W2777892103 cites W2096587251 @default.
- W2777892103 cites W2098432330 @default.
- W2777892103 cites W2101967659 @default.
- W2777892103 cites W2104688167 @default.
- W2777892103 cites W2110463517 @default.
- W2777892103 cites W2112154049 @default.
- W2777892103 cites W2117296173 @default.
- W2777892103 cites W2117738774 @default.
- W2777892103 cites W2120565308 @default.
- W2777892103 cites W2122231459 @default.
- W2777892103 cites W2125089843 @default.
- W2777892103 cites W2125764628 @default.
- W2777892103 cites W2126525177 @default.
- W2777892103 cites W2129155846 @default.
- W2777892103 cites W2132481390 @default.
- W2777892103 cites W2134070359 @default.
- W2777892103 cites W2136392296 @default.
- W2777892103 cites W2136493937 @default.
- W2777892103 cites W2138684035 @default.
- W2777892103 cites W2139893960 @default.
- W2777892103 cites W2141778626 @default.
- W2777892103 cites W2143588591 @default.
- W2777892103 cites W2144454079 @default.
- W2777892103 cites W2144876609 @default.
- W2777892103 cites W2146774191 @default.
- W2777892103 cites W2147044753 @default.
- W2777892103 cites W2149954869 @default.
- W2777892103 cites W2152839556 @default.
- W2777892103 cites W2153029275 @default.
- W2777892103 cites W2156576736 @default.
- W2777892103 cites W2157484248 @default.
- W2777892103 cites W2159664830 @default.
- W2777892103 cites W2159914115 @default.
- W2777892103 cites W2160343816 @default.
- W2777892103 cites W2161476733 @default.
- W2777892103 cites W2161948433 @default.
- W2777892103 cites W2164188362 @default.
- W2777892103 cites W2165766480 @default.
- W2777892103 cites W2166415858 @default.
- W2777892103 cites W2167759667 @default.
- W2777892103 cites W2169742866 @default.
- W2777892103 cites W2173367702 @default.
- W2777892103 cites W2188930066 @default.
- W2777892103 cites W2193792657 @default.
- W2777892103 cites W2266290735 @default.