FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2777894284> ?p ?o ?g. }

• W2777894284 endingPage "4" @default.
• W2777894284 startingPage "4" @default.
• W2777894284 abstract "Within the Pumwani sex worker cohort, a subgroup remains seronegative, despite frequent exposure to HIV-1; some of them seroconverted several years later. This study attempts to identify viral variations in 5'LTR-leader sequences (5'LTR-LS) that might contribute to the late seroconversion. The 5'LTR-LS contains sites essential for replication and genome packaging, viz, primer binding site (PBS), major splice donor (SD), and major packaging signal (PS). The 5'LTR-LS of 20 late seroconverters (LSC) and 122 early seroconverters (EC) were amplified, cloned, and sequenced. HelixTree 6.4.3 was employed to classify HIV subtypes and sequence variants based on seroconversion status. We find that HIV-1 subtypes A1.UG and D.UG were overrepresented in the viruses infecting the LSC (P < 0.0001). Specific variants of PBS (Pc < 0.0001), SD1 (Pc < 0.0001), and PS (Pc < 0.0001) were present only in the viral population from EC or LSC. Combinations of PBS [PBS-2 (Pc < 0.0001) and PBS-3 (Pc < 0.0001)] variants with specific SD sequences were only seen in LSC or EC. Combinations of A1.KE or D with specific PBS and SD variants were only present in LSC or EC (Pc < 0.0001). Furthermore, PBS variants only present in LSC co-clustered with PBS references utilizing tRNAArg; whereas, the PBS variants identified only in EC co-clustered with PBS references using tRNALys3 and its variants. This is the first report that specific PBS, SD1, and PS sequence variants within 5'LTR-LS are associated with HIV-1 seroconversion, and it could aid designing effective anti-HIV strategies." @default.
• W2777894284 created "2018-01-05" @default.
• W2777894284 creator A5004563927 @default.
• W2777894284 creator A5028900793 @default.
• W2777894284 creator A5042629291 @default.
• W2777894284 creator A5043233942 @default.
• W2777894284 creator A5066794848 @default.
• W2777894284 creator A5074922265 @default.
• W2777894284 date "2017-12-23" @default.
• W2777894284 modified "2023-09-25" @default.
• W2777894284 title "HIV-1 Subtypes and 5’LTR-Leader Sequence Variants Correlate with Seroconversion Status in Pumwani Sex Worker Cohort" @default.
• W2777894284 cites W1504782024 @default.
• W2777894284 cites W1524005178 @default.
• W2777894284 cites W1531756512 @default.
• W2777894284 cites W1583870669 @default.
• W2777894284 cites W1609063856 @default.
• W2777894284 cites W1830847181 @default.
• W2777894284 cites W1870661610 @default.
• W2777894284 cites W1898538816 @default.
• W2777894284 cites W1966747467 @default.
• W2777894284 cites W1966876898 @default.
• W2777894284 cites W1967984418 @default.
• W2777894284 cites W1970301294 @default.
• W2777894284 cites W1986732741 @default.
• W2777894284 cites W1994950355 @default.
• W2777894284 cites W2001079898 @default.
• W2777894284 cites W2005138146 @default.
• W2777894284 cites W2012937791 @default.
• W2777894284 cites W2016925221 @default.
• W2777894284 cites W2021204089 @default.
• W2777894284 cites W2022574383 @default.
• W2777894284 cites W2023134352 @default.
• W2777894284 cites W2031754540 @default.
• W2777894284 cites W2032087644 @default.
• W2777894284 cites W2037261712 @default.
• W2777894284 cites W2046459696 @default.
• W2777894284 cites W2051858217 @default.
• W2777894284 cites W2061660567 @default.
• W2777894284 cites W2062174477 @default.
• W2777894284 cites W2066701009 @default.
• W2777894284 cites W2070153049 @default.
• W2777894284 cites W2070230130 @default.
• W2777894284 cites W2070952619 @default.
• W2777894284 cites W2084799778 @default.
• W2777894284 cites W2088499375 @default.
• W2777894284 cites W2090647543 @default.
• W2777894284 cites W2093716355 @default.
• W2777894284 cites W2099616781 @default.
• W2777894284 cites W2102453921 @default.
• W2777894284 cites W2102463866 @default.
• W2777894284 cites W2106777870 @default.
• W2777894284 cites W2107383131 @default.
• W2777894284 cites W2110185508 @default.
• W2777894284 cites W2113990919 @default.
• W2777894284 cites W2116956383 @default.
• W2777894284 cites W2124533520 @default.
• W2777894284 cites W2125586839 @default.
• W2777894284 cites W2128830055 @default.
• W2777894284 cites W2131100298 @default.
• W2777894284 cites W2134840439 @default.
• W2777894284 cites W2138749294 @default.
• W2777894284 cites W2143712456 @default.
• W2777894284 cites W2144420913 @default.
• W2777894284 cites W2144553670 @default.
• W2777894284 cites W2146396346 @default.
• W2777894284 cites W2147988449 @default.
• W2777894284 cites W2148369218 @default.
• W2777894284 cites W2159181197 @default.
• W2777894284 cites W2162822797 @default.
• W2777894284 cites W2164521647 @default.
• W2777894284 cites W2167476707 @default.
• W2777894284 cites W2171304305 @default.
• W2777894284 cites W2419413022 @default.
• W2777894284 cites W4230123290 @default.
• W2777894284 doi "https://doi.org/10.3390/v10010004" @default.
• W2777894284 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5795417" @default.
• W2777894284 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29295533" @default.
• W2777894284 hasPublicationYear "2017" @default.
• W2777894284 type Work @default.
• W2777894284 sameAs 2777894284 @default.
• W2777894284 citedByCount "2" @default.
• W2777894284 countsByYear W27778942842022 @default.
• W2777894284 countsByYear W27778942842023 @default.
• W2777894284 crossrefType "journal-article" @default.
• W2777894284 hasAuthorship W2777894284A5004563927 @default.
• W2777894284 hasAuthorship W2777894284A5028900793 @default.
• W2777894284 hasAuthorship W2777894284A5042629291 @default.
• W2777894284 hasAuthorship W2777894284A5043233942 @default.
• W2777894284 hasAuthorship W2777894284A5066794848 @default.
• W2777894284 hasAuthorship W2777894284A5074922265 @default.
• W2777894284 hasBestOaLocation W27778942841 @default.
• W2777894284 hasConcept C153911025 @default.
• W2777894284 hasConcept C159047783 @default.
• W2777894284 hasConcept C178790620 @default.
• W2777894284 hasConcept C185592680 @default.
• W2777894284 hasConcept C2777451964 @default.
• W2777894284 hasConcept C2777563447 @default.
• W2777894284 hasConcept C2908647359 @default.

• next