Matches in SemOpenAlex for { <https://semopenalex.org/work/W2778045456> ?p ?o ?g. }
- W2778045456 endingPage "347" @default.
- W2778045456 startingPage "330" @default.
- W2778045456 abstract "A specialized, highly developed dermal extracellular matrix (ECM) provides the skin with its unique mechano-resilient properties and is vital for organ function. Accordingly, genetically acquired deficiency of dermal ECM proteins or proteins essential for the post-translational modification and homeostasis of the dermal ECM, results in diseases affecting the skin. Some of these diseases are lethal or lead to severe complications for the affected individuals. At present limited efficient and evidence-based treatment options exist for genetic ECM diseases of the skin. There is thus a high unmet medical need, creating an urgent demand to develop improved care for these diseases. Here, by drawing examples from the wealth of research on epidermolysis bullosa, we present the current status of biological and small molecule therapies for genetic ECM diseases with skin manifestations. We discuss challenges, and using existing data to propose strategies and future directions allowing development of more efficacious therapies and advancement of them into clinical practice." @default.
- W2778045456 created "2018-01-05" @default.
- W2778045456 creator A5036984757 @default.
- W2778045456 creator A5049773464 @default.
- W2778045456 creator A5084380415 @default.
- W2778045456 date "2018-10-01" @default.
- W2778045456 modified "2023-10-17" @default.
- W2778045456 title "Therapies for genetic extracellular matrix diseases of the skin" @default.
- W2778045456 cites W1504748568 @default.
- W2778045456 cites W1534731743 @default.
- W2778045456 cites W1589868959 @default.
- W2778045456 cites W1695562685 @default.
- W2778045456 cites W1717775186 @default.
- W2778045456 cites W1765051977 @default.
- W2778045456 cites W1855249480 @default.
- W2778045456 cites W1870255478 @default.
- W2778045456 cites W1934861956 @default.
- W2778045456 cites W1951110048 @default.
- W2778045456 cites W1967241081 @default.
- W2778045456 cites W1978035979 @default.
- W2778045456 cites W1980369120 @default.
- W2778045456 cites W1985848626 @default.
- W2778045456 cites W1987555596 @default.
- W2778045456 cites W1988158895 @default.
- W2778045456 cites W1988830115 @default.
- W2778045456 cites W1991274745 @default.
- W2778045456 cites W1994592243 @default.
- W2778045456 cites W1999004381 @default.
- W2778045456 cites W2002639721 @default.
- W2778045456 cites W2005330089 @default.
- W2778045456 cites W2005389545 @default.
- W2778045456 cites W2007516665 @default.
- W2778045456 cites W2008676437 @default.
- W2778045456 cites W2009761451 @default.
- W2778045456 cites W2013543032 @default.
- W2778045456 cites W2015848550 @default.
- W2778045456 cites W2016150075 @default.
- W2778045456 cites W2025419314 @default.
- W2778045456 cites W2037927128 @default.
- W2778045456 cites W2038469788 @default.
- W2778045456 cites W2040578546 @default.
- W2778045456 cites W2041262876 @default.
- W2778045456 cites W2046551884 @default.
- W2778045456 cites W2048704264 @default.
- W2778045456 cites W2055521188 @default.
- W2778045456 cites W2058726837 @default.
- W2778045456 cites W2059651841 @default.
- W2778045456 cites W2060458594 @default.
- W2778045456 cites W2062073850 @default.
- W2778045456 cites W2064773694 @default.
- W2778045456 cites W2065316185 @default.
- W2778045456 cites W2065840402 @default.
- W2778045456 cites W2076020457 @default.
- W2778045456 cites W2083004617 @default.
- W2778045456 cites W2084647146 @default.
- W2778045456 cites W2085600205 @default.
- W2778045456 cites W2086180233 @default.
- W2778045456 cites W2086381423 @default.
- W2778045456 cites W2087070256 @default.
- W2778045456 cites W2091785498 @default.
- W2778045456 cites W2095597500 @default.
- W2778045456 cites W2098214526 @default.
- W2778045456 cites W2101771841 @default.
- W2778045456 cites W2105425188 @default.
- W2778045456 cites W2117333824 @default.
- W2778045456 cites W2118834593 @default.
- W2778045456 cites W2119151191 @default.
- W2778045456 cites W2125243010 @default.
- W2778045456 cites W2125733524 @default.
- W2778045456 cites W2126253425 @default.
- W2778045456 cites W2129656993 @default.
- W2778045456 cites W2133976043 @default.
- W2778045456 cites W2135348048 @default.
- W2778045456 cites W2138812118 @default.
- W2778045456 cites W2140120791 @default.
- W2778045456 cites W2141209788 @default.
- W2778045456 cites W2141865949 @default.
- W2778045456 cites W2144062996 @default.
- W2778045456 cites W2144192090 @default.
- W2778045456 cites W2152350731 @default.
- W2778045456 cites W2158602154 @default.
- W2778045456 cites W2159796957 @default.
- W2778045456 cites W2167235468 @default.
- W2778045456 cites W2167266797 @default.
- W2778045456 cites W2169459855 @default.
- W2778045456 cites W2202126265 @default.
- W2778045456 cites W2207821817 @default.
- W2778045456 cites W2212364724 @default.
- W2778045456 cites W2229527959 @default.
- W2778045456 cites W2271930197 @default.
- W2778045456 cites W2276102155 @default.
- W2778045456 cites W2287894105 @default.
- W2778045456 cites W2291521583 @default.
- W2778045456 cites W2292011078 @default.
- W2778045456 cites W2299953595 @default.
- W2778045456 cites W2314571758 @default.
- W2778045456 cites W2325364010 @default.
- W2778045456 cites W232770196 @default.