Matches in SemOpenAlex for { <https://semopenalex.org/work/W2778090153> ?p ?o ?g. }
- W2778090153 abstract "The Neuroepithelial cell transforming gene 1A (Net1A) is a RhoA subfamily GEF that localizes to the nucleus in the absence of stimulation, preventing it from activating RhoA. Once relocalized in the cytosol, Net1A stimulates cell motility and extracellular matrix invasion. In the present work we investigated mechanisms responsible for Net1A cytosolic relocalization. We demonstrate that inhibition of MAPK pathways blocks Net1A relocalization, with cells being most sensitive to JNK pathway inhibition. Moreover, JNK or p38 MAPK activation is sufficient to elicit Net1A cytosolic localization. Net1A relocalization stimulated by EGF or JNK activation requires nuclear export by CRM1. JNK1 phosphorylates Net1A on serine 52, and alanine substitution of this site prevents Net1A relocalization caused by EGF or JNK activation. Glutamic acid substitution of this site is sufficient for Net1A relocalization and results in elevated RhoA signaling to stimulate myosin light chain phosphorylation and F-actin accumulation. Net1A S52E expression stimulates cell motility, enables Matrigel invasion, and promotes invadopodia formation. These data highlight a novel mechanism for controlling Net1A subcellular localization to regulate RhoA activation, cell motility, and invasion." @default.
- W2778090153 created "2018-01-05" @default.
- W2778090153 creator A5046674705 @default.
- W2778090153 creator A5051012185 @default.
- W2778090153 creator A5063154413 @default.
- W2778090153 creator A5082600587 @default.
- W2778090153 date "2017-01-01" @default.
- W2778090153 modified "2023-10-12" @default.
- W2778090153 title "Stress activated MAPKs and CRM1 regulate Net1A subcellular localization to control cell motility and invasion" @default.
- W2778090153 cites W1775421522 @default.
- W2778090153 cites W1899552864 @default.
- W2778090153 cites W1976385326 @default.
- W2778090153 cites W1978028702 @default.
- W2778090153 cites W1979720860 @default.
- W2778090153 cites W1980670952 @default.
- W2778090153 cites W1980900741 @default.
- W2778090153 cites W1989680815 @default.
- W2778090153 cites W1993450321 @default.
- W2778090153 cites W1994930469 @default.
- W2778090153 cites W1997442473 @default.
- W2778090153 cites W1997663906 @default.
- W2778090153 cites W1998809668 @default.
- W2778090153 cites W2000476522 @default.
- W2778090153 cites W2005918516 @default.
- W2778090153 cites W2011355386 @default.
- W2778090153 cites W2016312253 @default.
- W2778090153 cites W2022870393 @default.
- W2778090153 cites W2027608068 @default.
- W2778090153 cites W2027649846 @default.
- W2778090153 cites W2028919524 @default.
- W2778090153 cites W2034616962 @default.
- W2778090153 cites W2036169332 @default.
- W2778090153 cites W2036610908 @default.
- W2778090153 cites W2040125444 @default.
- W2778090153 cites W2040196938 @default.
- W2778090153 cites W2047994341 @default.
- W2778090153 cites W2057324165 @default.
- W2778090153 cites W2061448906 @default.
- W2778090153 cites W2071199281 @default.
- W2778090153 cites W2075569359 @default.
- W2778090153 cites W2077856249 @default.
- W2778090153 cites W2079356305 @default.
- W2778090153 cites W2082355820 @default.
- W2778090153 cites W2084472730 @default.
- W2778090153 cites W2088799165 @default.
- W2778090153 cites W2088966231 @default.
- W2778090153 cites W2093172971 @default.
- W2778090153 cites W2094140080 @default.
- W2778090153 cites W2094772268 @default.
- W2778090153 cites W2102312968 @default.
- W2778090153 cites W2104836622 @default.
- W2778090153 cites W2104896634 @default.
- W2778090153 cites W2105376455 @default.
- W2778090153 cites W2105746559 @default.
- W2778090153 cites W2108215899 @default.
- W2778090153 cites W2109571718 @default.
- W2778090153 cites W2114500007 @default.
- W2778090153 cites W2114941442 @default.
- W2778090153 cites W2115544017 @default.
- W2778090153 cites W2124241990 @default.
- W2778090153 cites W2127691143 @default.
- W2778090153 cites W2128795657 @default.
- W2778090153 cites W2130497526 @default.
- W2778090153 cites W2144925609 @default.
- W2778090153 cites W2146473598 @default.
- W2778090153 cites W2146965545 @default.
- W2778090153 cites W2149848093 @default.
- W2778090153 cites W2153358370 @default.
- W2778090153 cites W2154402616 @default.
- W2778090153 cites W2155149550 @default.
- W2778090153 cites W2158897126 @default.
- W2778090153 cites W2160938675 @default.
- W2778090153 cites W2170803963 @default.
- W2778090153 cites W2750717426 @default.
- W2778090153 cites W4238991694 @default.
- W2778090153 cites W4243541841 @default.
- W2778090153 doi "https://doi.org/10.1242/jcs.204644" @default.
- W2778090153 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5826041" @default.
- W2778090153 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29361525" @default.
- W2778090153 hasPublicationYear "2017" @default.
- W2778090153 type Work @default.
- W2778090153 sameAs 2778090153 @default.
- W2778090153 citedByCount "8" @default.
- W2778090153 countsByYear W27780901532018 @default.
- W2778090153 countsByYear W27780901532019 @default.
- W2778090153 countsByYear W27780901532021 @default.
- W2778090153 countsByYear W27780901532023 @default.
- W2778090153 crossrefType "journal-article" @default.
- W2778090153 hasAuthorship W2778090153A5046674705 @default.
- W2778090153 hasAuthorship W2778090153A5051012185 @default.
- W2778090153 hasAuthorship W2778090153A5063154413 @default.
- W2778090153 hasAuthorship W2778090153A5082600587 @default.
- W2778090153 hasBestOaLocation W27780901531 @default.
- W2778090153 hasConcept C11960822 @default.
- W2778090153 hasConcept C181199279 @default.
- W2778090153 hasConcept C190062978 @default.
- W2778090153 hasConcept C2776879804 @default.
- W2778090153 hasConcept C2777093181 @default.
- W2778090153 hasConcept C55493867 @default.
- W2778090153 hasConcept C57074206 @default.