Matches in SemOpenAlex for { <https://semopenalex.org/work/W2778152525> ?p ?o ?g. }
- W2778152525 endingPage "148" @default.
- W2778152525 startingPage "131" @default.
- W2778152525 abstract "Pancreatic ductal adenocarcinoma (PDAC) is projected to be the second leading cause of cancer related mortality in the United States in 2030, with a 5-year overall survival of less than 10% despite decades of extensive research. Pancreatic cancer is marked by the accumulation of complex molecular changes, complex tumor-stroma interaction, and an immunosuppressive tumor microenvironment. PDAC has proven to be resistant to many cytotoxic, targeted and immunologic treatment approaches. Areas covered: In this paper, we review the major areas of research in PDAC, with highlights on the challenges and areas of opportunity for personalized treatment approaches. Expert commentary: The focus of research in pancreatic cancer has moved away from developing conventional cytotoxic combinations. The marked advances in understanding the molecular biology of this disease especially in the areas of the microenvironment, metabolism, and DNA repair have opened new opportunities for developing novel treatment strategies. Improved understanding of molecular abnormalities allows the development of personalized treatment approaches." @default.
- W2778152525 created "2018-01-05" @default.
- W2778152525 creator A5011817630 @default.
- W2778152525 creator A5013768762 @default.
- W2778152525 creator A5043399313 @default.
- W2778152525 creator A5056962753 @default.
- W2778152525 date "2017-12-19" @default.
- W2778152525 modified "2023-10-10" @default.
- W2778152525 title "The evolution into personalized therapies in pancreatic ductal adenocarcinoma: challenges and opportunities" @default.
- W2778152525 cites W1497915798 @default.
- W2778152525 cites W1500816076 @default.
- W2778152525 cites W1541202145 @default.
- W2778152525 cites W1548935276 @default.
- W2778152525 cites W1558905924 @default.
- W2778152525 cites W1576073791 @default.
- W2778152525 cites W1580984542 @default.
- W2778152525 cites W1586288482 @default.
- W2778152525 cites W1607832269 @default.
- W2778152525 cites W1648301895 @default.
- W2778152525 cites W1775874433 @default.
- W2778152525 cites W1820495241 @default.
- W2778152525 cites W1838826168 @default.
- W2778152525 cites W1849018836 @default.
- W2778152525 cites W1859252938 @default.
- W2778152525 cites W1912177776 @default.
- W2778152525 cites W1922304500 @default.
- W2778152525 cites W1940241680 @default.
- W2778152525 cites W1940682904 @default.
- W2778152525 cites W1955920682 @default.
- W2778152525 cites W1961945002 @default.
- W2778152525 cites W1965531809 @default.
- W2778152525 cites W1966327293 @default.
- W2778152525 cites W1967220865 @default.
- W2778152525 cites W1968323734 @default.
- W2778152525 cites W1970527559 @default.
- W2778152525 cites W1974225259 @default.
- W2778152525 cites W1977122810 @default.
- W2778152525 cites W1979516313 @default.
- W2778152525 cites W1984803858 @default.
- W2778152525 cites W1987313243 @default.
- W2778152525 cites W1989732890 @default.
- W2778152525 cites W1991870390 @default.
- W2778152525 cites W1992995822 @default.
- W2778152525 cites W1995862211 @default.
- W2778152525 cites W2002962154 @default.
- W2778152525 cites W2003533730 @default.
- W2778152525 cites W2003541535 @default.
- W2778152525 cites W2005595167 @default.
- W2778152525 cites W2008482491 @default.
- W2778152525 cites W2008658155 @default.
- W2778152525 cites W2008945738 @default.
- W2778152525 cites W2010916968 @default.
- W2778152525 cites W2012176955 @default.
- W2778152525 cites W2015353751 @default.
- W2778152525 cites W2015942742 @default.
- W2778152525 cites W2015943054 @default.
- W2778152525 cites W2015961605 @default.
- W2778152525 cites W2019517037 @default.
- W2778152525 cites W2020080445 @default.
- W2778152525 cites W2023560058 @default.
- W2778152525 cites W2023783085 @default.
- W2778152525 cites W2024754519 @default.
- W2778152525 cites W2025970479 @default.
- W2778152525 cites W2026776398 @default.
- W2778152525 cites W2028897202 @default.
- W2778152525 cites W2030235885 @default.
- W2778152525 cites W2033329729 @default.
- W2778152525 cites W2035355251 @default.
- W2778152525 cites W2036907057 @default.
- W2778152525 cites W2037898576 @default.
- W2778152525 cites W2038750466 @default.
- W2778152525 cites W2039211343 @default.
- W2778152525 cites W2041888069 @default.
- W2778152525 cites W2043237658 @default.
- W2778152525 cites W2049522382 @default.
- W2778152525 cites W2050396069 @default.
- W2778152525 cites W2052617606 @default.
- W2778152525 cites W2054186497 @default.
- W2778152525 cites W2054373401 @default.
- W2778152525 cites W2054633892 @default.
- W2778152525 cites W2055091294 @default.
- W2778152525 cites W2055975580 @default.
- W2778152525 cites W2058591930 @default.
- W2778152525 cites W2060081030 @default.
- W2778152525 cites W2062703496 @default.
- W2778152525 cites W2063263557 @default.
- W2778152525 cites W2064512018 @default.
- W2778152525 cites W2065215232 @default.
- W2778152525 cites W2065346431 @default.
- W2778152525 cites W2066135299 @default.
- W2778152525 cites W2066969492 @default.
- W2778152525 cites W2068822045 @default.
- W2778152525 cites W2069723223 @default.
- W2778152525 cites W2070880677 @default.
- W2778152525 cites W2071411482 @default.
- W2778152525 cites W2071462987 @default.
- W2778152525 cites W2072525040 @default.
- W2778152525 cites W2074201366 @default.