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- W2778196172 abstract "Introduction: Clinical benefits of 100 mg SC Mepolizumab are modest when sputum eosinophilia was not controlled (CEA 2016;46:793-802). This study compared treatment response of weight-adjusted IV Reslizumab on patients previously treated with 100 mg SC Mepolizumab. Methods: 9 prednisone-dependent asthmatics (sputum eosinophils, median 29.3%, blood eosinophils 0.6x106/L), who had previously received Mepolizumab (Q4W) for at least 1 year, received two infusions of placebo (Q4W) followed by 4 infusions of 3.0 mg/kg Reslizumab Q4W in a single-blind, sequential trial. Primary outcomes were reduction of blood and sputum eosinophils. Eosinophil progenitor cells (EoPs), ILC2s, CD4+ lymphocytes were evaluated by flow cytometry. Sputum IL-5 was measured by ELISA. Results: IV Reslizumab attenuated sputum eosinophils (by 31.2±3% vs placebo 15.7±6%, p=0.003) and blood eosinophils (by 0.4±.1 vs placebo 0.05±.1, p=0.003) and this was associated with clinical improvements in FEV1 and ACQ (p Conclusions: Reslizumab IV was superior to Mepolizumab 100 mg SC in decreasing sputum eosinophils with improved asthma control in prednisone-dependent asthmatics." @default.
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- W2778196172 date "2017-09-01" @default.
- W2778196172 modified "2023-09-22" @default.
- W2778196172 title "Weight-adjusted Intravenous Reslizumab Attenuates Airway Eosinophilia in Severe Asthmatics compared to 100 mg Subcutaneous Mepolizumab" @default.
- W2778196172 doi "https://doi.org/10.1183/1393003.congress-2017.pa4768" @default.
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