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- W2778280326 abstract "This chapter explores the development, structure, and function of the lower airways. Sections 1 and 2 describe the anatomy, morphology, and distribution of the pulmonary innervation in pre- and postnatal murine, porcine, and human lungs. Recent advances in techniques (e.g., confocal microscopy, optical projection tomography) are reviewed with respect to their use in mutant/transgenic models, which have increased our understanding of pulmonary innervation throughout the pseudoglandular, canalicular, and saccular stages of development. Significant advances in our understanding of the potential role of the neuroendocrine cell system, including neuroepithelial bodies, are examined with respect to the origins of chemo- and mechano-sensation in the lung and the impact on airway regulation. Section 3 addresses pre- and postnatal airway smooth muscle function, while Section 4 provides an overview of the role of muscarinic receptors in the lung. In summary, this chapter documents the innervation of the lung and airway smooth muscle throughout development." @default.
- W2778280326 created "2018-01-05" @default.
- W2778280326 creator A5034107806 @default.
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- W2778280326 date "2014-01-01" @default.
- W2778280326 modified "2023-10-16" @default.
- W2778280326 title "Development of the Innervation of the Lower Airways" @default.
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