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- W2778295087 abstract "Galectin-3 is a soluble protein in the body that has been shown involvement in biologicalprocesses such as tumour growth and metastasis as well as auto immune disease. Moleculesdeveloped by Ulf Nilsson’s research group have shown inhibitory effect in in vitro and in vivostudies towards galecin-3 but to get detailed information about distribution in vivo studies usingPET should be performed. Precursors were developed and synthesized to obtain a product thatcould be radiolabelled with fluorine-18 and form a traceable galectin-3 inhibitor to see affinityand distribution in vivo. The synthesis was optimized to generate enough product to be able toperform several radiolabelling reactions. Three different precursors were tested with differentradiolabelling methods and conditions to obtain a high enough radiochemical yield and thenpurify the formed product to be able to see if the method could be used to proceed to animalexperiments. Out of the three the precursor to tracer 22 using a boronic pinacol ester leavinggroups facilitated by a Cu(OTf)2(pyr)4 catalyst showed a high radiochemical yield andpurification by preparative HPLC generated radiochemically pure product. Using the boronicpinacol ester precursor, radiolabelling it using the proposed method and purify it usingpreparative HPLC results in a product that can be taken to in vivo animal studies." @default.
- W2778295087 created "2018-01-05" @default.
- W2778295087 creator A5055041522 @default.
- W2778295087 date "2017-01-01" @default.
- W2778295087 modified "2023-09-27" @default.
- W2778295087 title "18-F Radiolabelling of Thiodigalactosides as Galectin-3 Inhibitors" @default.
- W2778295087 hasPublicationYear "2017" @default.
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