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- W2778297273 abstract "Introduction: COPD (Chronic Obstructive Lung Disease) is a heterogeneous disease of multiple phenotypes, on which eosinophilia in peripheral blood is increasingly discussed as a biomarker in the therapeutic response to corticosteroids, indicating inflammation and association with an increased risk of exacerbations. In Brazil, there is still no large study evaluating the serum dosage of eosinophils in COPD patients. Objective: The study aims to show the prevalence of eosinophilia in COPD patients. Methods: 252 patients diagnosed with COPD according to GOLD criteria (FEV/FVC Results: Out of the 252 patients, 132 (52.38%) had eosinophils ≥ 2% and, of these, 80 (31.7% of the total) presented eosinophils ≥ 3%. Of the total, 51 patients (20.2%) had eosinophils ≥ 300. In a secondary analysis, 53 patients (21%) had previous clinical history of atopy, of which only 13 had eosinophils ≥ 300 or 3%. The associated diagnosis of asthma (according to GOLD criteria) was present in 18 patients (7.14%), 4 of these with eosinophils ≥ 300 ou 3%. Conclusion: A large proportion of COPD patients have increased serum eosinophils, with an even greater difference when a cutoff point of 2% is used. Serum eosinophils dosage is important for therapeutic definition in COPD patients and still needs to be extensively studied in different populations." @default.
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- W2778297273 date "2017-09-01" @default.
- W2778297273 modified "2023-09-27" @default.
- W2778297273 title "Prevalence of eosinophilia in COPD patients in Brazil" @default.
- W2778297273 doi "https://doi.org/10.1183/1393003.congress-2017.pa3579" @default.
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