Matches in SemOpenAlex for { <https://semopenalex.org/work/W27783146> ?p ?o ?g. }
- W27783146 endingPage "90" @default.
- W27783146 startingPage "1181" @default.
- W27783146 abstract "A novel family of evolutionally conserved neuronal guidance cues, including ligands (i.e., Slit, netrin, epherin, and semaphorin) and their corresponding receptors (i.e., Robo, DCC/Unc5, Eph and plexin/ neuropilin), has been identified to play a crucial role in axon pathfinding and branching as well as neuronal cell migration. The presence of commonalities in both neural and vascular developments has led to some exciting discoveries recently, which have extended the functions of these systems to vascular formation (vasculogenesis) and development (angiogenesis). Some of these ligands and receptors have been found to be expressed in the vasculature and surrounding tissues in physiological and pathological conditions. It is postulated that they regulate the formation and integrity of blood vessels. In particular, it has been shown that the Slit/Robo pair plays a novel role in angiogenesis during tumorigenesis and vascular formation during embryogenesis. Herein we summarize briefly the characteristics of this family of neuronal guidance molecules and discuss the extra-neural expression and function of the Slit/Robo pair in angiogenesis in physiological and pathological settings. We report expression of Robo1 protein in capillary endothelium and co-expression of Slit2 and Robo1 proteins in syncytiotrophoblast in healthy term human placental villi. These cellular expression patterns implicate that the Slit/Robo signaling plays an autocrine and/or paracrine role in angiogenesis and trophoblast functions. We also speculate a possible role of this system in pathophysiological placental angiogenesis." @default.
- W27783146 created "2016-06-24" @default.
- W27783146 creator A5001051207 @default.
- W27783146 creator A5042849826 @default.
- W27783146 creator A5052427746 @default.
- W27783146 creator A5061585695 @default.
- W27783146 date "2010-09-01" @default.
- W27783146 modified "2023-09-23" @default.
- W27783146 title "Perspectives of SLIT/ROBO signaling in placental angiogenesis." @default.
- W27783146 cites W1495287184 @default.
- W27783146 cites W1549576586 @default.
- W27783146 cites W1561902389 @default.
- W27783146 cites W1567217875 @default.
- W27783146 cites W1568682367 @default.
- W27783146 cites W1611891438 @default.
- W27783146 cites W1619255491 @default.
- W27783146 cites W1917919273 @default.
- W27783146 cites W1964359283 @default.
- W27783146 cites W1965181820 @default.
- W27783146 cites W1965232435 @default.
- W27783146 cites W1965463560 @default.
- W27783146 cites W1967450020 @default.
- W27783146 cites W1967753069 @default.
- W27783146 cites W1974860284 @default.
- W27783146 cites W1976260945 @default.
- W27783146 cites W1977937744 @default.
- W27783146 cites W1979877257 @default.
- W27783146 cites W1982630896 @default.
- W27783146 cites W1983763042 @default.
- W27783146 cites W1985288684 @default.
- W27783146 cites W1985377144 @default.
- W27783146 cites W1988166118 @default.
- W27783146 cites W1988736580 @default.
- W27783146 cites W1992752619 @default.
- W27783146 cites W1992993638 @default.
- W27783146 cites W1994044440 @default.
- W27783146 cites W1994088328 @default.
- W27783146 cites W1994162941 @default.
- W27783146 cites W1996430165 @default.
- W27783146 cites W1996640278 @default.
- W27783146 cites W1996713062 @default.
- W27783146 cites W1998182442 @default.
- W27783146 cites W1998282976 @default.
- W27783146 cites W2006527348 @default.
- W27783146 cites W2007389030 @default.
- W27783146 cites W2010486643 @default.
- W27783146 cites W2010513401 @default.
- W27783146 cites W2010835536 @default.
- W27783146 cites W2013609300 @default.
- W27783146 cites W2014651004 @default.
- W27783146 cites W2019129382 @default.
- W27783146 cites W2020046465 @default.
- W27783146 cites W2024787221 @default.
- W27783146 cites W2025065524 @default.
- W27783146 cites W2026177356 @default.
- W27783146 cites W2029034327 @default.
- W27783146 cites W2029763523 @default.
- W27783146 cites W2033712349 @default.
- W27783146 cites W2034377665 @default.
- W27783146 cites W2036734716 @default.
- W27783146 cites W2041905383 @default.
- W27783146 cites W2043863730 @default.
- W27783146 cites W2048228486 @default.
- W27783146 cites W2048611498 @default.
- W27783146 cites W2050279712 @default.
- W27783146 cites W2053230581 @default.
- W27783146 cites W2053521423 @default.
- W27783146 cites W2056220715 @default.
- W27783146 cites W2056862346 @default.
- W27783146 cites W2061172411 @default.
- W27783146 cites W2062276405 @default.
- W27783146 cites W2062594120 @default.
- W27783146 cites W2068555773 @default.
- W27783146 cites W2071850213 @default.
- W27783146 cites W2072177711 @default.
- W27783146 cites W2072515549 @default.
- W27783146 cites W2073676627 @default.
- W27783146 cites W2077596106 @default.
- W27783146 cites W2078374322 @default.
- W27783146 cites W2078694475 @default.
- W27783146 cites W2079128745 @default.
- W27783146 cites W2081172496 @default.
- W27783146 cites W2083472943 @default.
- W27783146 cites W2085451074 @default.
- W27783146 cites W2085716177 @default.
- W27783146 cites W2086554023 @default.
- W27783146 cites W2086619383 @default.
- W27783146 cites W2087168597 @default.
- W27783146 cites W2088023695 @default.
- W27783146 cites W2089405081 @default.
- W27783146 cites W2089553333 @default.
- W27783146 cites W2089564289 @default.
- W27783146 cites W2089611230 @default.
- W27783146 cites W2090344258 @default.
- W27783146 cites W2091154399 @default.
- W27783146 cites W2093160853 @default.
- W27783146 cites W2094316880 @default.
- W27783146 cites W2099417196 @default.