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• W2778364860 abstract "Design and solid phase synthesis of the 1,3,4-oxadiazole based peptidomimetic library is presented. Library synthesis starts from the coupling of the thiosemicarbazide resin with Fmoc-protected amino acid following desulfurative cyclization to 1,3,4-oxadiazoles. Following substitution of the secondary amine with the 3-nitrobenzoyl functional group and its further reduction were performed. Thus, the functionalization with amino acids could be performed on both sides of the core skeleton. After diversification and cleavage from the resin using TFA: DCM cleavage cocktail, an enantiopure library of compounds was obtained. Further evaluation of physicochemical properties was performed." @default.
• W2778364860 created "2018-01-05" @default.
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• W2778364860 date "2018-02-01" @default.
• W2778364860 modified "2023-09-26" @default.
• W2778364860 title "Solid-phase parallel synthesis of 1,3,4-oxadiazole based peptidomimetic library as a potential modulator of protein-protein interactions" @default.
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• W2778364860 doi "https://doi.org/10.1016/j.tet.2017.12.055" @default.
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