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- W2778745093 abstract "<b>Background:</b> Obstructive sleep apnea (OSA) occurs when the upper airway narrows or collapses due to the loss of upper airway muscle activation at sleep onset. This study investigated the effectiveness of triggered kinesthetic stimulation in patients with OSA. <b>Methods:</b> A proof-of-concept, open-label, multicenter prospective study was conducted in 24 patients with severe OSA. During a one night evaluation, kinesthetic stimulation was intermittently delivered in 30 minute periods. The duration of apneas and hypopneas during <i>Stim<sub>on</sub></i> and <i>Stim<sub>off</sub></i> periods were compared. Five hospital-based university centers in France participated. Sleep studies were evaluated by a single scorer at a core laboratory (CHU Grenoble). <b>Results:</b> During the <i>Stim<sub>on</sub></i> phases, statistically significant decreases in durations of apnea and hypopneas were observed in 56% and 46% of patients, respectively. Overall, 75% of patients showed an improvement in apneas or hypopneas durations. The mean reduction in durations for patients with a significant decrease was 4.86 seconds for apneas and 6.00 seconds for hypopneas. Oxygen desaturation index (4%) decreased from 14.6 (29.3 – 7.3) to 13.9 (23.8 – 6.9)/hour when comparing <i>Stim<sub>off</sub></i> versus <i>Stim<sub>on</sub></i> periods. <b>Conclusions:</b> This proof of concept study is the first to identify kinesthetic stimulation as a potentially effective therapy for OSA. These data justify evaluation in a controlled study." @default.
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- W2778745093 date "2017-09-01" @default.
- W2778745093 modified "2023-10-15" @default.
- W2778745093 title "Kinesthetic stimulation for obstructive sleep apnea syndrome: an “on-off” proof of concept trial" @default.
- W2778745093 doi "https://doi.org/10.1183/1393003.congress-2017.pa2288" @default.
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