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- W2778876312 endingPage "390" @default.
- W2778876312 startingPage "390" @default.
- W2778876312 abstract "The DNA damage response (DDR) is a complex signalling network activated when DNA is altered by intrinsic or extrinsic agents. DDR plays important roles in genome stability and cell cycle regulation, as well as in tumour transformation. Viruses have evolved successful life cycle strategies in order to ensure a chronic persistence in the host, virtually avoiding systemic sequelae and death. This process promotes the periodic shedding of large amounts of infectious particles to maintain a virus reservoir in individual hosts, while allowing virus spreading within the community. To achieve such a successful lifestyle, the human papilloma virus (HPV) needs to escape the host defence systems. The key to understanding how this is achieved is in the virus replication process that provides by itself an evasion mechanism by inhibiting and delaying the host immune response against the viral infection. Numerous studies have demonstrated that HPV exploits both the ataxia-telangiectasia mutated (ATM) and ataxia-telangiectasia and rad3-related (ATR) DDR pathways to replicate its genome and maintain a persistent infection by downregulating the innate and cell-mediated immunity. This review outlines how HPV interacts with the ATM- and ATR-dependent DDR machinery during the viral life cycle to create an environment favourable to viral replication, and how the interaction with the signal transducers and activators of transcription (STAT) protein family and the deregulation of the Janus kinase (JAK)–STAT pathways may impact the expression of interferon-inducible genes and the innate immune responses." @default.
- W2778876312 created "2018-01-05" @default.
- W2778876312 creator A5001752773 @default.
- W2778876312 creator A5004012774 @default.
- W2778876312 creator A5006610478 @default.
- W2778876312 creator A5008008655 @default.
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- W2778876312 creator A5027259331 @default.
- W2778876312 creator A5030423282 @default.
- W2778876312 creator A5031908223 @default.
- W2778876312 creator A5082745772 @default.
- W2778876312 date "2017-12-19" @default.
- W2778876312 modified "2023-10-02" @default.
- W2778876312 title "How Human Papillomavirus Replication and Immune Evasion Strategies Take Advantage of the Host DNA Damage Repair Machinery" @default.
- W2778876312 cites W140061535 @default.
- W2778876312 cites W1675517407 @default.
- W2778876312 cites W1769456965 @default.
- W2778876312 cites W1891322286 @default.
- W2778876312 cites W1964067338 @default.
- W2778876312 cites W1966452991 @default.
- W2778876312 cites W1966676297 @default.
- W2778876312 cites W1972142721 @default.
- W2778876312 cites W1972256398 @default.
- W2778876312 cites W1972535275 @default.
- W2778876312 cites W1975728569 @default.
- W2778876312 cites W1976065177 @default.
- W2778876312 cites W1976675985 @default.
- W2778876312 cites W1980784347 @default.
- W2778876312 cites W1982342760 @default.
- W2778876312 cites W1992025025 @default.
- W2778876312 cites W1992452467 @default.
- W2778876312 cites W1993599921 @default.
- W2778876312 cites W1994710883 @default.
- W2778876312 cites W1997632425 @default.
- W2778876312 cites W1999064296 @default.
- W2778876312 cites W2005326726 @default.
- W2778876312 cites W2008242826 @default.
- W2778876312 cites W2008734149 @default.
- W2778876312 cites W2009546207 @default.
- W2778876312 cites W2010877179 @default.
- W2778876312 cites W2015732442 @default.
- W2778876312 cites W2025633815 @default.
- W2778876312 cites W2025699269 @default.
- W2778876312 cites W2031841054 @default.
- W2778876312 cites W2033628308 @default.
- W2778876312 cites W2034902271 @default.
- W2778876312 cites W2036069120 @default.
- W2778876312 cites W2040404177 @default.
- W2778876312 cites W2040653543 @default.
- W2778876312 cites W2040860750 @default.
- W2778876312 cites W2043188148 @default.
- W2778876312 cites W2044680553 @default.
- W2778876312 cites W2045346731 @default.
- W2778876312 cites W2047398843 @default.
- W2778876312 cites W2054676676 @default.
- W2778876312 cites W2056515323 @default.
- W2778876312 cites W2060496772 @default.
- W2778876312 cites W2061862766 @default.
- W2778876312 cites W2064116640 @default.
- W2778876312 cites W2064572112 @default.
- W2778876312 cites W2066332001 @default.
- W2778876312 cites W2068852707 @default.
- W2778876312 cites W2069422003 @default.
- W2778876312 cites W2071603995 @default.
- W2778876312 cites W2072915590 @default.
- W2778876312 cites W2075537604 @default.
- W2778876312 cites W2077436902 @default.
- W2778876312 cites W2078841246 @default.
- W2778876312 cites W2079929631 @default.
- W2778876312 cites W2083251817 @default.
- W2778876312 cites W2083960841 @default.
- W2778876312 cites W2086369200 @default.
- W2778876312 cites W2090870297 @default.
- W2778876312 cites W2092722802 @default.
- W2778876312 cites W2097555726 @default.
- W2778876312 cites W2099560139 @default.
- W2778876312 cites W2107635427 @default.
- W2778876312 cites W2108621249 @default.
- W2778876312 cites W2108720228 @default.
- W2778876312 cites W2112534911 @default.
- W2778876312 cites W2112817646 @default.
- W2778876312 cites W2125927306 @default.
- W2778876312 cites W2125949831 @default.
- W2778876312 cites W2126572576 @default.
- W2778876312 cites W2132520025 @default.
- W2778876312 cites W2139721691 @default.
- W2778876312 cites W2139891717 @default.
- W2778876312 cites W2140944306 @default.
- W2778876312 cites W2140963402 @default.
- W2778876312 cites W2143752982 @default.
- W2778876312 cites W2144103905 @default.
- W2778876312 cites W2146505724 @default.
- W2778876312 cites W2146912213 @default.
- W2778876312 cites W2153719039 @default.
- W2778876312 cites W2154012156 @default.
- W2778876312 cites W2155091868 @default.
- W2778876312 cites W2155985573 @default.
- W2778876312 cites W2156547418 @default.