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- W2778903699 endingPage "1008" @default.
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- W2778903699 abstract "We report the Ni-catalyzed Suzuki–Miyaura coupling of aliphatic amide derivatives. Prior studies have shown that aliphatic amide derivatives can undergo Ni-catalyzed carbon–heteroatom bond formation but that Ni-mediated C–C bond formation using aliphatic amide derivatives has remained difficult. The coupling disclosed herein is tolerant of considerable variation with respect to both the amide-based substrate and the boronate coupling partner and proceeds in the presence of heterocycles and epimerizable stereocenters. Moreover, a gram-scale Suzuki–Miyaura coupling/Fischer indolization sequence demonstrates the ease with which unique polyheterocyclic scaffolds can be constructed, particularly by taking advantage of the enolizable ketone functionality present in the cross-coupled product. The methodology provides an efficient means to form C–C bonds from aliphatic amide derivatives using nonprecious-metal catalysis and offers a general platform for the heteroarylation of aliphatic acyl electrophiles." @default.
- W2778903699 created "2018-01-05" @default.
- W2778903699 creator A5005865272 @default.
- W2778903699 creator A5022158260 @default.
- W2778903699 creator A5059979091 @default.
- W2778903699 creator A5091765956 @default.
- W2778903699 date "2018-01-05" @default.
- W2778903699 modified "2023-10-14" @default.
- W2778903699 title "Nickel-Catalyzed Suzuki–Miyaura Coupling of Aliphatic Amides" @default.
- W2778903699 cites W1159743676 @default.
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- W2778903699 cites W1943008936 @default.
- W2778903699 cites W1985267956 @default.
- W2778903699 cites W1987280477 @default.
- W2778903699 cites W1995895091 @default.
- W2778903699 cites W2003555872 @default.
- W2778903699 cites W2023912170 @default.
- W2778903699 cites W2028018476 @default.
- W2778903699 cites W2032731092 @default.
- W2778903699 cites W2035797410 @default.
- W2778903699 cites W2055454485 @default.
- W2778903699 cites W2057611763 @default.
- W2778903699 cites W2073868150 @default.
- W2778903699 cites W2082663466 @default.
- W2778903699 cites W2094871139 @default.
- W2778903699 cites W2104142278 @default.
- W2778903699 cites W2111729898 @default.
- W2778903699 cites W2135346135 @default.
- W2778903699 cites W2137047761 @default.
- W2778903699 cites W2167311327 @default.
- W2778903699 cites W2169156142 @default.
- W2778903699 cites W2204311646 @default.
- W2778903699 cites W2215466160 @default.
- W2778903699 cites W2237104335 @default.
- W2778903699 cites W2263756718 @default.
- W2778903699 cites W2273124147 @default.
- W2778903699 cites W2287574920 @default.
- W2778903699 cites W2317296363 @default.
- W2778903699 cites W2322888461 @default.
- W2778903699 cites W2338100037 @default.
- W2778903699 cites W2341379833 @default.
- W2778903699 cites W2398305159 @default.
- W2778903699 cites W2407505989 @default.
- W2778903699 cites W2418356847 @default.
- W2778903699 cites W2424593201 @default.
- W2778903699 cites W2494013278 @default.
- W2778903699 cites W2499867668 @default.
- W2778903699 cites W2501108172 @default.
- W2778903699 cites W2512639925 @default.
- W2778903699 cites W2523846442 @default.
- W2778903699 cites W2529166689 @default.
- W2778903699 cites W2546641655 @default.
- W2778903699 cites W2549417026 @default.
- W2778903699 cites W2555218601 @default.
- W2778903699 cites W2556601502 @default.
- W2778903699 cites W2559934293 @default.
- W2778903699 cites W2563042313 @default.
- W2778903699 cites W2570055317 @default.
- W2778903699 cites W2588833167 @default.
- W2778903699 cites W2592989676 @default.
- W2778903699 cites W2598646131 @default.
- W2778903699 cites W2599793474 @default.
- W2778903699 cites W2600131074 @default.
- W2778903699 cites W2603073582 @default.
- W2778903699 cites W2604410491 @default.
- W2778903699 cites W2608233938 @default.
- W2778903699 cites W2610550558 @default.
- W2778903699 cites W2611117591 @default.
- W2778903699 cites W2611737529 @default.
- W2778903699 cites W2620243243 @default.
- W2778903699 cites W2621292383 @default.
- W2778903699 cites W2622046301 @default.
- W2778903699 cites W2624805733 @default.
- W2778903699 cites W2667976850 @default.
- W2778903699 cites W2724551730 @default.
- W2778903699 cites W2725561759 @default.
- W2778903699 cites W2732218143 @default.
- W2778903699 cites W2741011467 @default.
- W2778903699 cites W2742693127 @default.
- W2778903699 cites W2745745497 @default.
- W2778903699 cites W2748612127 @default.
- W2778903699 cites W2760474393 @default.
- W2778903699 cites W2764150248 @default.
- W2778903699 cites W2765473704 @default.
- W2778903699 cites W2766593732 @default.
- W2778903699 cites W2770263884 @default.
- W2778903699 cites W2772740546 @default.
- W2778903699 cites W2949062535 @default.
- W2778903699 cites W2951652160 @default.
- W2778903699 cites W2952393861 @default.
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- W2778903699 doi "https://doi.org/10.1021/acscatal.7b03688" @default.
- W2778903699 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5906067" @default.
- W2778903699 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29682398" @default.
- W2778903699 hasPublicationYear "2018" @default.
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