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- W2779164803 abstract "RNA-binding proteins (RBPs) can control each step of the mRNA life cycle, such as splicing, nuclear export, stability, degradation, localization, and translation efficiency. Thus, RBPs can modulate the final amount of protein level and play an important role in fine-tuning many cellular processes. Surprisingly, the role of specific RBPs to allow the dynamic and coordinated expression of functionally related mitochondrial proteins has begun to emerge only recently. These RBPs define specific post-transcriptional RNA regulons that fine-tune mitochondrial gene expression, thus tailoring the effects of broad transcriptional responses to specific demands or affecting mitochondrial biogenesis independently from de novo transcription. Moreover, a handful of RBPs promote translation of mitochondrial proteins in close proximity to the organelle. Here, we review the molecular components that play a role in these elaborate and flexible mechanisms, and discuss the physiological implications of post-transcriptional regulation for mitochondrial function." @default.
- W2779164803 created "2018-01-05" @default.
- W2779164803 creator A5006785929 @default.
- W2779164803 creator A5012477668 @default.
- W2779164803 date "2018-06-01" @default.
- W2779164803 modified "2023-10-17" @default.
- W2779164803 title "Post-transcriptional regulation of mitochondrial function" @default.
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- W2779164803 doi "https://doi.org/10.1016/j.cophys.2017.12.008" @default.
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