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- W2779171844 abstract "Thrombotic thrombocytopenic purpura (TTP) is characterized by microangiopathic hemolytic anemia and a consumptive thrombocytopenia, as a result of severe deficiency of ADAMTS13. The standard of care of the acute episode is treatment with plasma exchange and immunosuppression. After the acute episode is resolved, patients face a significant risk of relapse and long-term complications associated with significant morbidity and even mortality. Novel treatments have been under development and will be discussed in this review. Caplacizumab, a nanobody that blocks the interaction between VWF and platelets, has shown promising results in decreasing the time to recover from the acute events that will hopefully translate into long-term clinical benefit for patients. In addition, identifying biomarkers to allow us to better predict the risk for relapse and the development of these long-term complications in patients with TTP are a few of the challenges that require our attention moving forward." @default.
- W2779171844 created "2018-01-05" @default.
- W2779171844 creator A5053638396 @default.
- W2779171844 creator A5079236034 @default.
- W2779171844 date "2018-01-01" @default.
- W2779171844 modified "2023-10-06" @default.
- W2779171844 title "Novel therapies in thrombotic thrombocytopenic purpura" @default.
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- W2779171844 doi "https://doi.org/10.1002/rth2.12066" @default.
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