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- W2779382641 abstract "Acetylcholine is a neuromodulator that shapes information processing in different cortical and subcortical areas. Cell type and location specific cholinergic receptor distributions suggest that acetylcholine in macaque striate cortex should boost feed-forward driven activity, while also reducing population excitability by increasing inhibitory tone. Studies using cholinergic agonists in anesthetized primate V1 have yielded conflicting evidence for such a proposal. Here we investigated how muscarinic or nicotinic receptor blockade affect neuronal excitability and contrast response functions in awake macaque area V1. Muscarinic or nicotinic receptor blockade caused reduced activity for all contrasts tested, without affecting the contrast where neurons reach their half maximal response (c50). The activity reduction upon muscarinic and nicotinic blockade resulted in reduced neuronal contrast sensitivity, as assessed through neurometric functions. In the majority of cells receptor blockade was best described by a response gain model (a multiplicative scaling of responses), indicating that ACh is involved in signal enhancement, not saliency filtering in macaque V1." @default.
- W2779382641 created "2018-01-05" @default.
- W2779382641 creator A5010566087 @default.
- W2779382641 creator A5039673234 @default.
- W2779382641 creator A5050754541 @default.
- W2779382641 date "2017-12-19" @default.
- W2779382641 modified "2023-10-13" @default.
- W2779382641 title "Muscarinic and Nicotinic Contribution to Contrast Sensitivity of Macaque Area V1 Neurons" @default.
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- W2779382641 doi "https://doi.org/10.3389/fncir.2017.00106" @default.
- W2779382641 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5742228" @default.
- W2779382641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29311843" @default.
- W2779382641 hasPublicationYear "2017" @default.
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